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Neuroprotective Effect of Quercetin in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Model of Parkinson’s Disease
Neda Nikokalam Nazif, Maryam Khosravi *, Ramesh Ahmadi, Maryam Bananej, Ahmad Majd
Department of Biology, Faculty of Biological Sciences, North-Tehran Branch, Islamic Azad University, Tehran, Iran , maryam-khosravi@iau-tnb.ac.ir
Abstract:   (144 Views)
Introduction: Parkinson's disease (PD) is a common neuropathological disorder caused by degeneration of dopaminergic neurons in the substantia nigra pars compacta. Quercetin (SNPC) is a compound with both anti-inflammatory and anti-oxidant effects, which can cross the blood brain barrier. The aim of the present study was to evaluate neuroprotective effect of quercetin in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced model of PD in male mice. Materials and Methods: 48 male NMRI mice were divided into 6 groups (n=8); control, saline, MPTP, MPTP+ 20mg/kg quercetin, MPTP+ 25mg/kg quercetin, and MPTP+ 30mg/kg quercetin. To induce PD model, MPTP (25mg/ Kg) was injected intraperitoneally (i.e.) for 4 day. Catalepsy test was assessed by test bars one and 21 days after the last injection MPTP. Quercetin (20, 25, 30mg/kg/day) was applied orally for 21 days. Dopaminergic neurons of SNPC were determined by immunohistochemical labeling. The levels of interleukin 10 and TNF-α were determined in the substantia nigra and the striatum using ELISA technique. Results: Treatment with quercetin was significantly improved catalepsy. Furthermore, quercetin significantly enhanced the number of neurons in SNPC, increased interleukin 10 protein levels, and reduced TNF-α protein values. Conclusion: Quercetin may exert a neuroprotective effect on progressive cell damage and the neuronal death in the substantia nigra in PD; possibly via modulation of inflammatory mediators.
Keywords: 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine, Quercetin, Mice
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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