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دوره 9 شماره 2 صفحات 79-90 برگشت به فهرست نسخه ها
تأثیر ژل رویال بر افسردگی و اضطراب در مدل حیوانی بیماری آلزایمر
مریم عظیم پور، محمد فتحی*، امید دزفولیان
گروه تربیت‌بدنی، دانشکده علوم انسانی، دانشگاه لرستان، خرم‌آباد، ایران ، Fathi.m@lu.ac.ir
چکیده:   (264 مشاهده)
مقدمه: ژل رویال ممکن است اثرات مثبتی بر عملکرد سیستم اعصاب مرکزی اعمال نماید، هدف از تحقیق حاضر بررسی تأثیر ژل رویال بر افسردگی و اضطراب در مدل موش‌های آلزایمری شده ناشی از تری‌متیل‌تین بوده است. مواد و روش‌ها: 32 سر موش صحرایی به‌ طور تصادفی به چهار گروه تقسیم شدند؛ سالم (HC)، (AD)، شم (SH) و تحت درمان با ژل رویال (RJ). آزمون شنای اجباری (FST) برای افسردگی و آزمون ارزیابی اضطراب با ماز بعلاوه (صلیبی) مرتفع (EMP) انجام شد. بیان ژن‌ در نمونه‌ها با استفاده از تکنیک ریل‌تام اندازه‌گیری شد. یافته‌ها: متغیر وابسته بی‌حرکتی به‌ طور معنی‌داری در گروه‌ AD نسبت به گروه‌های HC و RJ افزایش یافته است؛ به‌علاوه گروه SH شاخص بی‌حرکتی بیشتری را نسبت به گروه HC نشان داده است. شاخص‌های آنتی‌اکسیدانی سوپر اکسید دیسموتاز و گلوتاتیون پروکسیداز به‌طور معنی‌داری در گروه RJ بیشتر از گروه‌های SH و AD شد، همچنین این شاخص‌ها در گروه HC بیشتر از گروه‌های SH و AD گردید؛ گروه‌های RJ و HC در مقایسه با سایر گروه‌ها کاهش معنی‌داری در رفتارهای اضطرابی از خود نشان دادند. نتیجه‌گیری: مکمل RJ توانایی تعدیل خلق و خو را در موش‌های صحرایی مدل تری‌متیل‌تینی آلزایمر دارد و ممکن است اثرات مفیدی در درمان آلزایمر داشته باشد.
واژه‌های کلیدی: افسردگی، اضطراب، شنا کردن
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نوع مطالعه: پژوهشي | موضوع مقاله: بازتوانی و توانبخشی اعصاب
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Azimpour M, Fathi M, Dezfoulian O. The Effect of Royal Jelly on Depression and Anxiety in an Animal Model of Alzheimer's Disease. Shefaye Khatam. 2021; 9 (2) :79-90
URL: http://shefayekhatam.ir/article-1-2098-fa.html

عظیم پور مریم، فتحی محمد، دزفولیان امید. تأثیر ژل رویال بر افسردگی و اضطراب در مدل حیوانی بیماری آلزایمر. مجله علوم اعصاب شفای خاتم. 1400; 9 (2) :79-90

URL: http://shefayekhatam.ir/article-1-2098-fa.html



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دوره 9، شماره 2 - ( بهار 1400 ) برگشت به فهرست نسخه ها
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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