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:: Volume 8, Issue 3 (Summer - 2020) ::
Shefaye Khatam 2020, 8(3): 80-96 Back to browse issues page
The Role of Neural Tissue Engineering in the Repair of Nerve Lesions
Arash Abdolmaleki *, Asdollah Asadi, Leila Taghizadeh Momen, Shadi Parsi Pilerood
a. Department of Engineering Sciences, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran. b. Bio Sciences and Biotechnology Research Center (BBRC), Sabalan University of Advanced Technologies (SUAT), Namin, Iran , Abdolmalekiarash1364@gmail.com
Abstract:   (310 Views)
Introduction: Tissue engineering is the science of tissue design for the healing and regeneration of tissue lesions. Peripheral nerves are typically in danger of physical injury. Peripheral nerve injuries can cause by construction and transport accidents, natural disasters, war-related injuries, and surgical complications. Spontaneous repair of the peripheral nerve is often incomplete, with poor functional recovery. Therefore, nerve tissue engineering researchers have invented scaffolds that can help neural tissue repair due to the type of conformation and their constituents. If the nerve gap in the peripheral nervous system is less than 1 cm in length, the two ends of the gap can be surgically connected, for larger gaps neural autograft is the gold standard. Applying autograft is restricted due to the deficiency of donor nerves and the requirement of multiple surgeries. The central nervous system is more challenging as the neural repair inhibitor environment is created after injury. Therefore, design of various scaffolds to facilitate nerve tissue repair and regeneration could be a promising method to overcome these problems. Conclusion: Nervous system tissue engineering using nerve scaffolds is one of the therapeutic approaches to replace damaged nerve tissue. To this end, this paper examines the properties of ideal scaffolds and the biomaterials used in scaffold construction, as well as the cells and growth factors appropriate for the treatment of nerve lesions.
Keywords: Tissue Engineering, Peripheral Nerves, Central Nervous System, Regenerative Medicine
Full-Text [PDF 843 kb]   (56 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience
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Abdolmaleki A, Asadi A, Taghizadeh Momen L, Parsi Pilerood S. The Role of Neural Tissue Engineering in the Repair of Nerve Lesions. Shefaye Khatam. 2020; 8 (3) :80-96
URL: http://shefayekhatam.ir/article-1-2126-en.html

Volume 8, Issue 3 (Summer - 2020) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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