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:: Volume 8, Issue 4 (Autumn 2020) ::
Shefaye Khatam 2020, 8(4): 1-11 Back to browse issues page
The Effect of Hesperidin on the Cognitive-Behavioral Deficit in a Rat Model of Pentylenetetrazole-Induced Perinatal Seizures
Habibollah Khodabandeh , Shaghayegh Keshavarzi , Pariya Moradian , Mohammad Amin Edalatmanesh *
Department of Biology, Facultyof Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran , amin.edalatmanesh@gmail.com
Abstract:   (3174 Views)
Introduction: Perinatal seizure with inducing oxidative stress causes serious damage to the fetal central nervous system and leads to cognitive-behavioral deficits. This study evaluates the effect of Hesperidin (HES) on cognitive and behavioral deficits in rats following perinatal seizures. Materials and Method: 30 Wistar pregnant rats were randomly divided into 5 groups: control, pentylenetetrazole (PTZ) + NS, PTZ + HES 25, PTZ + HES50, and PTZ + HES 100. Animals were treated with repeated PTZ administration (40 mg/kg, intraperitoneally) from gestation day 14 for 5 consecutive days. Two hours before PTZ injection, the PTZ+NS group and the PTZ+HES groups were gavaged with either normal saline or HES (25, 50, or 100 mg/kg), respectively. The severity of seizure, delay in onset of a seizure in mothers, working and avoidance memory, and anxiety-like behaviors were assessed in one-month-old male infants. Results: A significant increase in seizure severity and a decrease in seizure delay were seen in PTZ-treated mothers. On the other hand, a significant decrease in behavior changes, avoidance memory, and hippocampal cell density was observed with increased anxiety levels in the infant of the PTZ+NS group compared to the control rats. However, HES-treated groups showed a significant increase in working and passive avoidance memory with a decreasing level of anxiety compared to the PTZ+NS group. Conclusion: HES has anticonvulsant, anxiolytic, and memory-enhancing effects in the perinatal seizures in rats.
Keywords: Seizures, Pregnancy, Cognition, Rats
Full-Text [PDF 993 kb]   (1191 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience
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Khodabandeh H, Keshavarzi S, Moradian P, Edalatmanesh M A. The Effect of Hesperidin on the Cognitive-Behavioral Deficit in a Rat Model of Pentylenetetrazole-Induced Perinatal Seizures. Shefaye Khatam 2020; 8 (4) :1-11
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Volume 8, Issue 4 (Autumn 2020) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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