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:: Volume 10, Issue 3 (Summer 2022) ::
Shefaye Khatam 2022, 10(3): 26-36 Back to browse issues page
The Effectiveness of Transcranial Electrical Stimulation on the Pattern of Brain Waves and Blood Pressure in Patients with Generalized Anxiety Disorder
Mahtab Baghaei , Mahmoud Tabatabaei *
2- Department of Physiology, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran , smt1351@gmail.com
Abstract:   (1439 Views)
Introduction: Transcranial direct current stimulation is considered one of the treatment methods for mental disorders. Materials and Methods: The aim of this study was to evaluate the effectiveness of transcranial direct current stimulation on the delta, theta, alpha, beta, and systolic and diastolic blood pressure in patients with generalized anxiety disorder. The present study was a double-blind intervention with a pre-test and post-test design on people with generalized anxiety disorder in Tabriz, Iran. 30 patients with generalized anxiety disorder were selected by purposive sampling method based on the criteria specified in DSM-5 and randomly divided into an experimental group (n = 15) and a control group (n=15). The experimental group received 10 sessions of 30 minutes of transcranial direct current stimulation with an intensity of 2mA in the dorsolateral prefrontal cortex and the control group also received artificial stimulation. Results: The results showed that transcranial direct current stimulation reduced delta and theta waves and increased beta and brain alpha waves in the experimental group. On the other hand, this method also showed a significant decrease in systolic and diastolic blood pressure in these patients. Conclusion: The results show that transcranial direct current stimulation has a significant effect on brain waves and blood pressure. Furthermore, this non-invasive method can be used as a therapeutic approach in people with generalized anxiety disorder.
Keywords: Transcranial Direct Current Stimulation, Dorsolateral Prefrontal Cortex, Anxiety Disorders
Full-Text [PDF 838 kb]   (1378 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience
References
1. Fisher P L, Durham R C. Psychopathology of generalized anxietydisorder. The Medicine Publishing Company Ltd.2004. [DOI:10.1383/psyt.3.4.26.32906]
2. Sadock, B., & Sadock, V. Kaplan & Sadock's comprehensive textbookof psychiatry. New York: Williams & Wilkins; 2005.
3. Barlow, D. H.Anxiety and its disorders: The nature and treatment ofanxiety and panic (2nd ed.). New York:Guilford Press; 20023.Barlow, D. H. Anxiety and its disorders: The nature and treatment of anxiety and panic (2nd ed.). New York: Guilford Press; 2002
4. Denollet, J, Vaes, J, & Brutsaert, D. L. Inadequate response to treatment in .coronary heart disease: adverse effects of Type D personality and younger age on 55-year prognosis and quality of life. Circulation 2000;102, 630-35. [DOI:10.1161/01.CIR.102.6.630]
5. Segalovitz J. Biofeedback and dance performance: a preliminary investigation. Journal of Appel Psychophysiology Biofeedback 2005;30(1): 65-74. [DOI:10.1007/s10484-005-2175-x]
6. Yoval greenberg, GH. Executive Function Deficits in vStudents With.Mathemetical Learning Disorder. Journal of Advances in Cognitive Sceince 2008; 14(3), 75-84.
7. Sebaban, V. To see but not to Read: The Magnocellular Theory of Dyslexia. Journal of Trends in Neuroscience 1999;20 (4): 147-152. [DOI:10.1016/S0166-2236(96)01005-3]
8. Klimesch, W. "EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis". Brain Research. Brain Research Reviews 1999; 29, 169-95. [DOI:10.1016/S0165-0173(98)00056-3]
9. Lineu, C., Fonseca, Glória M.A.S. Tedrus, Marcelo, G, Chiodi Jaciara, Näf Cerqueira, Josiane M.F. Tonelotto. QUANTITATIVE EEG IN CHILDREN WITH LEARNING DISABILITIES. Journal of Arq Neuropsiquiatr 2006;64(2): 376-81. [DOI:10.1590/S0004-282X2006000300005]
10. McCarthy M, Beaumont J.G, Thompson R, Peacock S. Modality-specific aspects of sustained and divided attentional performance in multiple sclerosis. Journal of Archives Clinical Neuropsychology 2001; 20(4): 705-18. [DOI:10.1016/j.acn.2005.04.007]
11. Lubar, J. F, & Shouse, M. N. EEG and behavioral changes in a hyperactive child concurrent with training of the sensorimotor rhythm (SMR): A preliminary report. Journal of Biofeedback & Self-Regulation 2004; 1(3): 293-06. [DOI:10.1007/BF01001170]
12. Kuo MF, Chen PS, Nitsche MA. The application of TDCS for the treatment of psychiatric diseases. Intrev psychiatry. 2017; 29(2): 146-67. [DOI:10.1080/09540261.2017.1286299]
13. Kuo MF, Paulus W, Nitsche MA. Therapeutic effects of non-invasive brain stimulation with direct currents (tDCS) in neuropsychiatric diseases. Neuroimage. 2014; 85: 948-60. [DOI:10.1016/j.neuroimage.2013.05.117]
14. Nitsche MA, Kou MF, Karrasch R, Wachter B, Liebetanz D, Paulus W. Serotonin affects transcranial direct current-induced neuroplasticity in humans. Biol Psychiat. 2009; 66(5): 503-8. [DOI:10.1016/j.biopsych.2009.03.022]
15. Brunoni A, Nitche M, Loo C. Transcranial direct current stimulation in neuropsychiatric disorders. Springer international publishing; 2016. P. 29-269. [DOI:10.1007/978-3-319-33967-2]
16. Bikson, M, Grossman, P, Thomas, C, Zannou, A, Jiang, J, Adnan, T, Mourdoukoutas, A. P, Kronberg, G, Truong, D, Boggio, P, Brunoni, A. R, Charvet, L, Fregni, F, Fritsch, B, Gillick,.B, Hamilton, R. H, Hampstead, B. M, Jankord, R, Kirton, A. Woods, A. transcranial Direct Current Stimulation for major Depression: A General System for Quantifying transcranial Elecrtotherapy Dosage. Current Treatment Options in Neurology 2018; 10(5) 377-85.
17. Krause MR, Zanos TP, Csorba BA, Pilly PK, Choe J, Phillips ME, Datta A, Pack CC. Transcranial direct current stimulation facilitates associative learning and alters functional connectivity in the primate brain. Current Biology. 2017; 23; 27(20): 3086-96. [DOI:10.1016/j.cub.2017.09.020]
18. Iannone A, Cruz A.P, Brasil-Neto J.P, Boechat-Barros R. Transcranial magnetic stimulation and transcranial direct current stimulation appear to be safe neuromodulatory techniques useful in the treatment of anxiety disorders and other neuropsychiatric disorders, Arq. Neuropsiquiatr. 74(10) 2016; 829-35. [DOI:10.1590/0004-282X20160115]
19. Sadeghi Bimorgh M, Omidi A, Ghoreishi FS, Rezaei Ardani A, Ghaderi A, Banafshe HR. The Effect of Transcranial Direct Current Stimulation on Relapse, Anxiety, and Depression in Patients With Opioid Dependence Under Methadone Maintenance Treatment: A Pilot Study. Frontiers in Pharmacology. 2020; 3; 11: 401. [DOI:10.3389/fphar.2020.00401]
20. Sauvaget A, Poulet E, Mantovani A, Bulteau S, Damier P, Moutaud B, Paternoster M, de Bartolomeis A, D'Urso G. The psychiatric neuromodulation unit: implementation and management. The journal of ECT. 2018; 34(4): 211-9. [DOI:10.1097/YCT.0000000000000513]
21. Sauvaget A, Lagalice L, Schirr-Bonnans S, Volteau C, Péré M, Dert C, Rivalland A, Tessier F, Lepage A, Tostivint A, Deschamps T. Cost-utility analysis of transcranial direct current stimulation (tDCS) in non-treatment-resistant depression: the DISCO randomised controlled study protocol. BMJ open. 2020; 10(1). [DOI:10.1136/bmjopen-2019-033376]
22. D'Urso G, Brunoni AR, Mazzaferro MP, Anastasia A, de Bartolomeis A, Mantovani A. Transcranial direct current stimulation for obsessive-compulsive disorder: a randomized, controlled, partial crossover trial. Depression and anxiety. 2016; 33(12): 1132-40. [DOI:10.1002/da.22578]
23. D'Urso G, Mantovani A, Patti S, Toscano E, de Bartolomeis A. Transcranial direct current stimulation in obsessive-compulsive disorder, posttraumatic stress disorder, and anxiety disorders. The journal of ECT. 2018; 34(3): 172-81. [DOI:10.1097/YCT.0000000000000538]
24. Ferrucci R, Mrakic-Sposta S, Gardini S, Ruggiero F, Vergari M, Mameli F, Arighi A, Spallazzi M, Barocco F, Michelini G, Pietroboni AM. Behavioral and neurophysiological effects of transcranial direct current stimulation (tDCS) in fronto-temporal dementia. Frontiers in behavioral neuroscience. 2018; 12: 235. [DOI:10.3389/fnbeh.2018.00235]
25. Kunze T, Hunold A, Haueisen J, Jirsa V, Spiegler A. Transcranial direct current stimulation changes resting state functional connectivity: A large-scale brain network modeling study. Neuroimage. 2016; 140: 174-87. [DOI:10.1016/j.neuroimage.2016.02.015]
26. Garcia S, Nalven M, Ault A, Eskenazi MA. tDCS as a treatment for anxiety and related cognitive deficits. International Journal of Psychophysiology. 2020; 158: 172-7. [DOI:10.1016/j.ijpsycho.2020.10.006]
27. Stein DJ, Medeiros LF, Caumo W, Torres IL. Transcranial direct current stimulation in patients with anxiety: current perspectives. Neuropsychiatric Disease and Treatment. 2020; 16: 161. [DOI:10.2147/NDT.S195840]
28. Fang G, Wang Y. Transcranial direct current stimulation (tDCS) produce anti-anxiety response in acute stress exposure rats via activation of amygdala CB1R. Behavioural Brain Research. 2020; 113050. [DOI:10.1016/j.bbr.2020.113050]
29. Vicario CM, Salehinejad MA, Felmingham K, Martino G, Nitsche MA. A systematic review on the therapeutic effectiveness of non-invasive brain stimulation for the treatment of anxiety disorders. Neuroscience & Biobehavioral Reviews. 2019; 96: 219-31. [DOI:10.1016/j.neubiorev.2018.12.012]
30. Heeren A, Billieux J, Philippot P, De Raedt R, Baeken C, de Timary P, Maurage P, Vanderhasselt MA. Impact of transcranial direct current stimulation on attentional bias for threat: a proof-of-concept study among individuals with social anxiety disorder. Social cognitive and affective neuroscience. 2017; 12(2): 251-60. [DOI:10.1093/scan/nsw119]
31. He Z, Liu Z, Zhao J, Elliott R, Zhang D. Improving emotion regulation of social exclusion in depression-prone individuals: a tDCS study targeting right VLPFC. Psychological Medicine. 2019; 1-2. [DOI:10.1017/S0033291719002915]
32. Dubreuil-Vall L, Chau P, Ruffini G, Widge AS, Camprodon JA. tDCS to the left DLPFC modulates cognitive and physiological correlates of executive function in a state-dependent manner. Brain Stimulation. 2019; 12(6): 1456-63. [DOI:10.1016/j.brs.2019.06.006]
33. Imburgio MJ, Orr JM. Effects of prefrontal tDCS on executive function: Methodological considerations revealed by meta-analysis. Neuropsychologia. 2018; 117: 156-66. [DOI:10.1016/j.neuropsychologia.2018.04.022]
34. Vicario, A., Martinez, C.D., Baretto, D,Casale, A. D., & Nicolasi, L.Hypertension and cognitivedecline: impacton executive function. Journal of ClinicalHypertension2005;7, 598-604. [DOI:10.1111/j.1524-6175.2005.04498.x]
35. Kuo, H.k, Sorond, F, Iloputaife, I, Gagnon, M, Milberg, W, & Lipsitz, L. A. Effect of blood pressure on cognitive functions in elderly persons. Journal of Gerontology 2004; 1191-194. [DOI:10.1093/gerona/59.11.1191]
36. Muela H C S, Costa-Hong VA, Yassuda MS, Moraes N C, Memoria C M, Machado M F, …& Nitrini R. Hypertension severity is associated with impaired cognitive performance. Journal of American Heart Association.2017;6(1), 1-11. [DOI:10.1161/JAHA.116.004579]
37. Iadecola C. (2016). Impact of hypertension on cognitive function: A scientific statement from the American Heart Association. Journal of Hypertension.2016;68(6), 67-94. [DOI:10.1161/HYP.0000000000000053]
38. Brunoni A, Ferrucci R, Bortolomasi M, VergariM, Tadini L, Boggio P, et al. Transcranial direct current stimulation (tDCS) in unipolar vs. bipolardepressive disorder. Progress in NeuroPsychopharmacol Biolo Psychiatr. 2011; 35(1): 96-101. [DOI:10.1016/j.pnpbp.2010.09.010]
39. Janicak PG, Davis JM, Gibbons RD, Ericksen S,Chang S, Gallagher P. Efficacy of ECT: A metaanalysis. Am J Psychiatr. 1625; 141(6): 297-302.
40. Batista EK, Klauss J, Fregni F, Nitsche MA, Nakamura-Palacios EM. A randomized placebo-controlled trial of targeted prefrontal cortex modulation with bilateral tDCS in patients with crack-cocaine dependence. International Journal of Neuropsychopharmacology.2015; 1; 18(12): pyv066. [DOI:10.1093/ijnp/pyv066]
41. He Z, Liu Z, Zhao J, Elliott R, Zhang D. Improving emotion regulation of social exclusion in depression-prone individuals: a tDCS study targeting right VLPFC. Psychological Medicine 2019; 16: 1-2. [DOI:10.1017/S0033291719002915]
42. Chrysikou EG, Gorey C, Aupperle RL. Anodal transcranial direct current stimulation over right dorsolateral prefrontal cortex alters decision making during approach-avoidance conflict. Social cognitive and affective neuroscience 2017; 12(3): 468-75. [DOI:10.1093/scan/nsw140]
43. Lin Y, Zhang C, Wang Y. A randomized controlled study of transcranial direct current stimulation in treatment of generalized anxiety disorder. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation 2019; 12(2): 403. [DOI:10.1016/j.brs.2018.12.302]
44. Heeren A, Billieux J, Philippot P, De Raedt R, Baeken C, de Timary P, Maurage P, Vanderhasselt MA. Impact of transcranial direct current stimulation on attentional bias for threat: a proof-of-concept study among individuals with social anxiety disorder. Social cognitive and affective neuroscience 2017; 1; 12(2): 251-60. [DOI:10.1093/scan/nsw119]
45. Garcia S, Nalven M, Ault A, Eskenazi MA. tDCS as a treatment for anxiety and related cognitive deficits. International Journal of Psychophysiology 2020; 1; 158: 172-7. [DOI:10.1016/j.ijpsycho.2020.10.006]
46. de Lima AL, Braga FM, da Costa RM, Gomes EP, Brunoni AR, Pegado R. Transcranial direct current stimulation for the treatment of generalized anxiety disorder: a randomized clinical trial. Journal of affective disorders 2019; 1; 259: 31-7. [DOI:10.1016/j.jad.2019.08.020]
47. Movahed FS, Goradel JA, Pouresmali A, Mowlaie M. Effectiveness of transcranial direct current stimulation on worry, anxiety, and depression in generalized anxiety disorder: a randomized, single-blind pharmacotherapy and sham-controlled clinical trial. Iranian Journal of Psychiatry and Behavioral Sciences 2018; 1; 12(2) (Persian). [DOI:10.5812/ijpbs.11071]
48. Zilverstand A, Parvaz MA, Goldstein RZ. Neuroimaging cognitive reappraisal in clinical populations to define neural targets for enhancing emotion regulation. A systematic review. Neuroimage 2017; 1; 151: 105-16. [DOI:10.1016/j.neuroimage.2016.06.009]
49. Duval ER, Javanbakht A, Liberzon I. Neural circuits in anxiety and stress disorders: a focused review. Therapeutics and clinical risk management 2015; 11: 115. [DOI:10.2147/TCRM.S48528]
50. Luigjes J, Segrave R, de Joode N, Figee M, Denys D. Efficacy of invasive and non-invasive brain modulation interventions for addiction. Neuropsychology review 2019; 15; 29(1): 116-38. [DOI:10.1007/s11065-018-9393-5]
51. Todder D, Gershi A, Perry Z, Kaplan Z, Levine J, Avirame K. Immediate effects of transcranial direct current stimulation on obsession-induced anxiety in refractory obsessive-compulsive disorder: a pilot study. The journal of ECT 2018; 1; 34(4): e51-7. [DOI:10.1097/YCT.0000000000000473]
52. Nitsche MA, Koschack J, Pohlers H, Hullemann S, Paulus W, Happe S. Effects of frontal transcranial direct current stimulation on emotional state and processing in healthy humans. Frontiers in psychiatry 2012; 18; 3: 58. [DOI:10.3389/fpsyt.2012.00058]
53. Clarke PJ, Sprlyan BF, Hirsch CR, Meeten F, Notebaert L. tDCS increases anxiety reactivity to intentional worry. Journal of psychiatric research 2020; 1; 120: 34-9. [DOI:10.1016/j.jpsychires.2019.10.013]

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Baghaei M, Tabatabaei M. The Effectiveness of Transcranial Electrical Stimulation on the Pattern of Brain Waves and Blood Pressure in Patients with Generalized Anxiety Disorder. Shefaye Khatam 2022; 10 (3) :26-36
URL: http://shefayekhatam.ir/article-1-2318-en.html
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Volume 10, Issue 3 (Summer 2022) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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