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Evaluation of Short-and Long-Term Pretreatment with the Flavonoid Rutin on Postoperative Pain in a Rat Paw Incision Model
Elham Eslahi , Amir Bavafa , Ali Pourbagher , Aboalfazl Shakeri , Fatemeh Forouzanfar *
a. Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. b. Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. , forouzanfarff@gmail.com
Abstract:   (9 Views)
Introduction: Postoperative pain remains a significant clinical challenge, often prolonging recovery and increasing the risk of chronic pain. Rutin, a flavonoid with antioxidant and anti-inflammatory properties, offers a multifaceted approach to pain modulation. The objective of this study was to evaluate both acute perioperative and long-term preventive effects of rutin on postoperative pain via dual modulation of hyperalgesia and allodynia in a rat paw incision model. Materials and Methods: This experimental study was conducted on male Wistar rats using both short-term and long-term pretreatment protocols. In the first study, the flavonoid rutin was administered orally at doses of 5, 10, and 20 mg/kg, starting 20 minutes before surgery and continuing for seven days post-surgery. In the second study, the same doses were administered from seven days before surgery until seven days after surgery. Mechanical allodynia, thermal hyperalgesia, and cold allodynia were assessed from 2 hours up to 7 days postoperatively. Results: Surgical intervention led to mechanical allodynia, thermal hyperalgesia, and cold allodynia, compared to the control group. The flavonoid rutin, particularly at a dose of 20 mg/kg, significantly reduced both allodynia and hyperalgesia compared with the postoperative pain group. Conclusion: The administration of long-term, routine flavonoid pretreatment may intercept early sensitization processes, mitigating the transition to chronic postoperative pain.
 
Keywords: Pain Management, Analgesia, Herbal Medicine
Full-Text [DOCX 948 kb]   (3 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Pain
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