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:: Volume 2, Issue 3 (Summer - 2014) ::
Shefaye Khatam 2014, 2(3): 53-64 Back to browse issues page
Propagation of Spreading Depression: A Review of Different Hypothesis
Mahmoud Lotfinia * , Ahmad Ali Lotfinia , Babak Khodaie , Milad Ahmadi , Sina Asaadi , Maryam Jafarian
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , mdla617@yahoo.com
Abstract:   (3987 Views)

Introduction: Spreading depression is a transient and self-propagating wave of neuronal and glial depolarization, followed by a temporary loss of brain activities. Spreading depression is known by a huge redistribution of ions between extra- and intracellular spaces and spreads at the velocity of 2-3 mm/min in all directions. Investigations indicate the role of spreading depression in several neurological disorders, including migraine with aura, epilepsy, traumatic brain injuries, transient global amnesia, stroke, and spinal cord diseases. Conclusion: Despite decades of research and hundreds of reports on the mechanism of spreading depression propagation, the exact mechanism of propagation still need to be elucidated. The present study reviews a group of these observations, in order to give some new insights into the complex mechanism of the propagation of spreading depression.

Keywords: Cortical Spreading Depression, Astrocytes, Gap Junctions
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Neurophysiology



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Lotfinia M, Lotfinia A A, Khodaie B, Ahmadi M, Asaadi S, Jafarian M. Propagation of Spreading Depression: A Review of Different Hypothesis. Shefaye Khatam. 2014; 2 (3) :53-64
URL: http://shefayekhatam.ir/article-1-304-en.html


Volume 2, Issue 3 (Summer - 2014) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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