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:: Volume 2, Issue 3 (Summer - 2014) ::
Shefaye Khatam 2014, 2(3): 65-76 Back to browse issues page
The Role of Dopamine Receptors during Brain Development
Sajad Sahab Negah , Zabihollah Khaksar , Hadi Kazemi , Hadi Aligholi , Maryam Safahani , Mostafa Modarres Mousavi Sayed, Shahin Mohammad Sadeghi *
Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , drshmsadeghi@gmail.com
Abstract:   (3689 Views)

Introduction: Brain development requires a complex interplay of genetic and environmental factors. Disruption of these elements can affect neuronal structure, function, or connectivity and can alter developmental trajectory. Neurotransmitters and neuromodulators, such as dopamine, participate in a wide range of behavioral and cognitive functions in the adult brain. Dopamine-mediated signaling plays a fundamental neurodevelopmental role in forebrain differentiation and circuit formation. In addition, D1 and D2 dopaminergic receptors activation influences neuronal proliferation, migration and differentiation. Conclusion: As dopamine receptors affect the developing brain and play an essential role in adult brain, better understanding of the role of these receptors in different regions of the developing brain can be helpful for treatment of brain developmental disorders.

Keywords: Dopamine, Growth and Development, Brain
Full-Text [PDF 713 kb]   (2979 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Molecular Neurobiology



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Sahab Negah S, Khaksar Z, Kazemi H, Aligholi H, Safahani M, Modarres Mousavi M et al . The Role of Dopamine Receptors during Brain Development. Shefaye Khatam. 2014; 2 (3) :65-76
URL: http://shefayekhatam.ir/article-1-306-en.html


Volume 2, Issue 3 (Summer - 2014) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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