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:: Volume 1, Issue 2 (Spring - 2013) ::
Shefaye Khatam 2013, 1(2): 21-26 Back to browse issues page
The Effect of Caloric Restriction on the Seizure Behaviors in Rats
Sanaz Moghadami , Elham Mohammadzadeh , Fariba Karimzadeh *
a. Shefa Neuroscience Research Center, Tehran, Iran. b. Tehran University of Medical Science, Tehran, Iran , Fariba_karimzade@yahoo.com
Abstract:   (7748 Views)

Introduction: Caloric restriction (CR) has been considered as a kind of diet therapy for some neurological diseases. This study was aimed to investigate the effect of CR on the seizure behavior induced in rats. Materials & Methods: CR was applied with deprivation of food and water for 24 hours every other day for a period of four weeks. Seizure induced by pentylenetetrazol (PTZ) injection. Animals in CR1 group were accessed caloric restriction before PTZ injection. Animals in CR2 group were accessed caloric restriction after PTZ injection. Animals in CR3 group were accessed caloric restriction before and after PTZ injection. Results: The scores of seizure behaviors were significantly decreased in groups of animals that received CR before PTZ injection. Conclusion: These findings suggest the CR reduces scores of seizure behaviour and may be helpful in the refractory epilepsy.

Keywords: Caloric restriction, Diet Therapy, Seizure
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neurophysiopathology



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Moghadami S, Mohammadzadeh E, Karimzadeh F. The Effect of Caloric Restriction on the Seizure Behaviors in Rats. Shefaye Khatam. 2013; 1 (2) :21-26
URL: http://shefayekhatam.ir/article-1-32-en.html


Volume 1, Issue 2 (Spring - 2013) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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