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The Effect of Spreading Depression on Memory Consolidation in Juvenile Wistar Rats
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Babak Khodaie *   , Ahmad Ali Lotfinia , Mahmoud Lotfinia |
| a. Shefa Neuroscience Research Center, Tehran, Iran. b. Faculty of Veterinary of Medicine, Karaj Islamic Azad University, Karaj, Iran. , vet_Babak@yahoo.com |
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Abstract: (12926 Views) |
| Introduction: Spreading depression (SD) play a role in some neurological disorders. SD is a depolarization wave, which pass through the brain and linked with large changes in cellular and molecular elements. Many of these changes play role in SD injuries pathophysiology. ECoG recording showed a transient hyperactivity, followed by depression of cellular activity. Cellular death and electrical changes are postulated to play central role in SD outcome as well as memory impairment. Materials & Methods: In the present study 24 Wistar rat were used to investigate repetitive SD effect on different aspect of memory. First the roles of SD on spatial memory retrieval have been discussed and then memory consolidation has been investigated by T-Maze test. Results: T-maze test result during four weeks analysis for spatial memory and also eight weeks for memory consolidation showed that both spatial memory and memory consolidation was significantly disrupt by SD induction. Conclusion: We conclude that SD induced brain electrical wave distribution could play important role in memory consolidation and memory retrieval during spatial memory test. |
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| Keywords: Cortical Spreading Depression, Brain Waves, Memory Disorders, Rats |
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Full-Text [PDF 2456 kb]
(2799 Downloads)
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Type of Study: Research --- Open Access, CC-BY-NC |
Subject:
Neurophysiopathology
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