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:: Volume 2 - The Autumn Supplement of Shefaye Khatam 3 - ::
Shefaye Khatam 2014, 2 - The Autumn Supplement of Shefaye Khatam 3 -: 46-46 Back to browse issues page
W3: A Controllable Brain Injury Model with a Defined Size for Evaluation of Tissue Engineered Products
Hadi Aligholi * , Maryam Safahani , Sajad Sahab Negah , Mostafa Modarres Mousavi
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. , aligholihadi@gmail.com
Abstract:   (5215 Views)
Brain injury has a multiple pathophysiology for which there is no definite treatment. In this regard, tissue engineering is one of the probable strategies for repair of damaged tissue. But creating a proper model for testing the engineered products faced some difficulties, specially, when we want to evaluate the effects of a product on the volume of injury. The current brain injury methods couldn’t provide defined brain tissue damage. We propose a new method to solve the problem. Previously, we introduced a new method for harvesting subventricular tissue from adult rat brain using a modified semi-automatic biopsy needle. We showed that a defined volume of tissue harvested from a specific area of brain without any adverse effect on other regions. We suggest using this biopsy procedure for creating a brain injury model with a defined size. Using this controllable biopsy method, we can test engineered products in a rat model of brain injury and assessed the volume of cavity after performing treatments in different groups.
Keywords: Brain Injury, Subventricular Tissue, Biopsy
Full-Text [PDF 200 kb]   (1746 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neurosurgery

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Aligholi H, Safahani M, Sahab Negah S, Modarres Mousavi M. W3: A Controllable Brain Injury Model with a Defined Size for Evaluation of Tissue Engineered Products . Shefaye Khatam 2014; 2 (S3) :46-46
URL: http://shefayekhatam.ir/article-1-505-en.html
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 2 - The Autumn Supplement of Shefaye Khatam 3 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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