[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
Main Menu
Home::
Journal Information::
Articles Archive::
Guide for Authors::
For Reviewers::
Ethical Statements::
Registration::
Site Facilities::
Contact us::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Copyright Policies

 

AWT IMAGE

 

..
Open Access Policy

This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

..
:: Volume 2 - The Autumn Supplement of Shefaye Khatam 3 - ::
Shefaye Khatam 2014, 2 - The Autumn Supplement of Shefaye Khatam 3 -: 60-60 Back to browse issues page
P10: Effects of Female Gonadal Hormones on Neuromedin S and its Receptor Following Experimental Traumatic Brain Injury
Fatemeh Maghool * , Mohammad Khaksari , Gholamreza Asadi karam
Neuroscience Research Center, School of Medicine, Kerman University of Medical Science, Kerman, Iran. , f.maghool@gmail.com
Abstract:   (5296 Views)
Brain edema plays an important role in secondary tissue damage following traumatic brain injury (TBI) but the underlying mechanisms are not entirely elucidated. The G protein coupled receptor FM-4 and its ligands, neuromedin S (NMS) and neuromedin U (NMU), are expressed in diverse brain areas, and have a variety of roles in nociception, inflammation, and stress but their probable changes after brain trauma has not yet been investigated. In the current study, we investigated the effect of low and high physiological levels of progesterone (P4) and 17β-estradiol (E2) replacements on brain NMS and NMU and expression of FM-4 as well as cerebral edema following TBI. Female Albino N-Mari rats were given female sex steroid hormones by capsule implantation for one week before brain injury or were not given hormone replacement therapy. The animal groups were included: Ovariectomized (OVX)+low estradiol (LE), OVX+high estradiol (HE), OVX+low progesterone (LP), OVX+high progesterone (HP), OVX+TBI, blank, vehicle (Veh). At 24 hrs after trauma, brain edema was estimated by measuring the brain water content. expression of prepro-NMS and FM-4, and the NMU protein content were evaluated. The results demonstrated that following TBI, the cerebral water content in (OVX+HP) and (OVX+HE) groups was less than in TBI untreated groups (P<0.01). Quantitative real time PCR indicated the higher expression of FM-4 gene and western blot analyses revealed an increase in prepro-NMS protein expression in progesterone-replaced rats compared to the both traumatic-unreplaced and estradiol-replaced groups. Our findings suggest that progesterone-replacement attenuates brain edema and induces an enhance in prepro-NMS and FM-4 mRNA expression which may mediate the anti-edematous effects of this hormone following TBI.
Keywords: Trauma Brain Injury, Esrtadiol, Progesterone, Neuromedin U, Neuromedin S
Full-Text [PDF 186 kb]   (1711 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Maghool F, Khaksari M, Asadi karam G. P10: Effects of Female Gonadal Hormones on Neuromedin S and its Receptor Following Experimental Traumatic Brain Injury. Shefaye Khatam 2014; 2 (S3) :60-60
URL: http://shefayekhatam.ir/article-1-519-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 2 - The Autumn Supplement of Shefaye Khatam 3 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.05 seconds with 45 queries by YEKTAWEB 4645