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P76: The Neuroprotective Roles of NMDA Receptors Antagonist Against with Lesion in Central Nucleus of Amygdala
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Milad Ahmadi *   , Azadeh Sajadian , Hadi Aligholi , Babak Khodaie , Ahmad Ali Lotfinia , Mahmoud Lotfinia |
| a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Faculty of Veterinary Medicine, Islamic Azad University, Karaj Branch, Karaj, Iran. , pmiladz@gmail.com |
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Abstract: (4638 Views) |
| The N-Methyl-D-aspartic acid (NMDA) receptor is one of the specific types of ionotropic receptors which lied to glutaminergic system. It has been widely accepted that NMDA receptor neurons promote anxiety, in humans as well as in animal models. However, in the previous study seems inhibiting of this receptors decreased the protective role in neural cell. Demonstration of NMDA receptor activity had neurodegeneration effect. The hypothesis of this study based on evaluated neuroprotectivity effect of NMDA receptor inhibition in the central nucleus of the amygdala (CeA) which have role in anxiety. In this study, we confirm that NMDA antagonist (MK801) is neuroprotective when CeA had confronted regional electrical lesion. Kindling of amygdala by electrical lesion which presented by stimulation of the CeA area after microinjection of MK801 (0.5 and 0.75 µg/kg) in the kindling area is may indicate neuroprotection from secondary injury. It seems the rats were confronted electrical lesion indicated specific decreases in the percentage of open arm time and percentage of open arm entries in elevated plus maze. However, in histopathological study, the mean of dark neurons of CeA in the MK801 group was less than lesion group. We concluded that inhibited of NMDA receptors in CeA neurons may contribute to induced neuroprotection by electrical lesion. |
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| Keywords: NMDA receptor, Neurodegenerative, Dark Neuron |
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Full-Text [PDF 196 kb]
(1584 Downloads)
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Type of Study: Research --- Open Access, CC-BY-NC |
Subject:
Basic research in Neuroscience
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