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:: Volume 2, Issue 1 (Winter - 2014) ::
Shefaye Khatam 2014, 2(1): 31-39 Back to browse issues page
Investigation of Chemical Composition of Lippia Citriodora: Essential Oil of Lippia Citriodora Promote Survival of PC12 Cells Following Treatment With H2O2
Sahar Babaei Abrak, Rahele Zhiani *
Department of Chemistry, Faculty of Sciences, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran , R_zhiani2006@yahoo.com
Abstract:   (9252 Views)

Introduction: Lemon herbena (Lippia citriodora) is a member of Verbenaceae family. This plant is endemic to South America and can growth in other areas, such as Iran. The aim of this study was to investigate and compare the chemical composition of the two production plants in the greenhouse and field of a lemon. Materials and Methods: Plants were cultivated in a Sarayan Ferdowsi area (south of Khorasan). Fourth kg of leaves was collected. Then, essential oil was extracted from fresh leaves using water and steam distillation. Finally, we treated PC12 cells with the essential oil that obtained from Lippia citriodora. The cell viability was evaluated by the MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolium bromide) assay. Results: Our results from GC-MS (Gas chromatography–mass spectrometry) method showed that greenhouse and field samples contained 0.68% and 0.62% (w/w), respectively. In addition, the data showed that the essential oil decreased oxidative stress-induced PC12 cell death. Conclusion: The results suggest that Lippia citriodora could be a potential candidate for treatment of neurodegenerative diseases.

Keywords: Gas Chromatography-Mass Spectrometry, Verbenaceae, Oxidative Stress, PC12 Cells
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience



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Babaei Abrak S, Zhiani R. Investigation of Chemical Composition of Lippia Citriodora: Essential Oil of Lippia Citriodora Promote Survival of PC12 Cells Following Treatment With H2O2. Shefaye Khatam. 2014; 2 (1) :31-39
URL: http://shefayekhatam.ir/article-1-59-en.html


Volume 2, Issue 1 (Winter - 2014) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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