[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
:: Volume 3, Issue 1 (Winter - 2015) ::
Shefaye Khatam 2015, 3(1): 131-144 Back to browse issues page
Role of MicroRNAs in Development of Immune Cells and Nervous System and their Relation to Multiple Sclerosis
Neda Parvini, Shamseddin Ahmadi *
Department of Biological Science and Biotechnology, Faculty of Science, University of Kurdistan, Sanandaj, Iran. , sh.ahmadi@uok.ac.ir
Abstract:   (8139 Views)

Introduction: MicroRNAs (miRNAs) are small and non-coding ribonucleic acids that play critical roles in regulation of host genome expression at post-transcriptional level. An individual miRNA is able to down-regulate multiple targeted mRNA transcripts. Therefore, minor changes in a miRNA expression may lead to significant alterations in the expression of different genes. During last two decades, miRNAs have emerged as key regulators of immune cell lineage differentiation, maturation, maintenance of immune homeostasis, and normal function. Multiples sclerosis (MS) is a chronic inflammatory disease that is characterized by infiltration of lymphocytes into the central nervous system (CNS), demyelination and axonal degeneration. Although causes of MS are still unknown, it is widely accepted that novel drug targets need to focus on both decreasing inflammation and promoting CNS repair. Recent researches about MS disease have shown that miRNAs are dysregulated in the immune system and CNS, which shows their role in the MS pathogenesis. Conclusion: Identification of specific expression patterns of miRNA in autoimmune diseases and a further comprehensive understanding of their role in the pathogenesis of different diseases offers promise of not only novel molecular diagnostic markers but also new gene therapy strategies for treating inflammatory autoimmune diseases. In this study, we review the latest findings about miRNA biogenesis and signatures in the CNS and immune cells of MS patients.

Keywords: MicroRNAs, Inflammation, Autoimmunity, Central Nervous System, Demyelinating Diseases
Full-Text [PDF 1474 kb]   (13558 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Neuroimmunology



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Parvini N, Ahmadi S. Role of MicroRNAs in Development of Immune Cells and Nervous System and their Relation to Multiple Sclerosis. Shefaye Khatam. 2015; 3 (1) :131-144
URL: http://shefayekhatam.ir/article-1-647-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 3, Issue 1 (Winter - 2015) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 4463