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:: Volume 2, Issue 1 (Winter - 2014) ::
Shefaye Khatam 2014, 2(1): 69-74 Back to browse issues page
Laminin Position as One of the Important Components of the Extracellular Matrix in Tissue Engineering of Nervous System
Shahin Mohammad Sadeghi, Sajad Sahab Negah, Zabihollah Khaksar *, Hadi Kazemi, Hadi Aligholi
Histology and Embryology group, Basic Science Department, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran , khaksar@shirazu.ac.ir
Abstract:   (9093 Views)

Introduction: Brain damage is often irreversible due to poor brain's self-repairing ability. New treatment strategies focused on stem cell therapy and 3-dimension matrix for brain tissue injury. The extracellular matrix (ECM) of animal tissues is a complex mixture of macromolecules that play an essential instructional role in the development of tissues and organs. Therefore, tissue engineering approaches rely on the need to present the correct cues to cells and to guide them to maintain tissue-specific functions. Recent research efforts on ECM have showed various sequences and motifs, which play key roles in improvement of the brain function after injury. Conclusion: Small motif from ECM molecules can mimic some of the biological functions of their large molecules. Peptides sequences and motifs laminin can be linked to various biomaterials scaffolds and provide the cells with mechanical support. This may ensure appropriate cell growth that aids the formation of the correct tissue structure.

Keywords: Laminin, Extracellular Matrix, Tissue Engineering, Nervous System
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Mohammad Sadeghi S, Sahab Negah S, Khaksar Z, Kazemi H, Aligholi H. Laminin Position as One of the Important Components of the Extracellular Matrix in Tissue Engineering of Nervous System. Shefaye Khatam. 2014; 2 (1) :69-74
URL: http://shefayekhatam.ir/article-1-65-en.html

Volume 2, Issue 1 (Winter - 2014) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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