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:: Volume 3, Issue 1 (Winter - 2015) ::
Shefaye Khatam 2015, 3(1): 36-41 Back to browse issues page
Role of Laterodorsal Thalamic Nucleus during Absence Seizure Attacks
Ahmad Ali Lotfinia, Maryam Jafarian, Mostafa Modarres Mousavi1, Hassan Hosseini Ravandi, Fariba Karimzadeh *
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. , Fariba_karimzade@yahoo.com
Abstract:   (6326 Views)

Introduction: A typical absence epilepsy is a type of nonconvulsive and generalized epilepsy. The main feature of these attacks is a sudden brief impairment of consciousness. The disturbances in thalamocortical loop play an important role in pathogenesis of absence seizures. However, it is not clear that which part of this network triggers the seizure. This study was aimed to investigate the role of latrodorsal (LD) thalamic neurons during spike and wave discharges (SWDs) in WAG/Rij rats, as the most valid animal model of absence epilepsy. Materials and Methods: Single unit activities in the LD thalamic nucleus and electrocorticogram of somatosensory cortex were simultaneously recorded in six-month-old WAG/Rij rats. Results: During SWDs, unit activity in the LD thalamic nucleus showed burst-like discharges, which were started before the peak component of SWDs. In SWD-free periods, burst like activity in the LD was reduced. Conclusion: Our findings suggest that the burst firing of LD may stimulate the neocortex to exhibit SWDs. It can be concluded that inhibition of burst firing of LD neurons may reduce the frequency of SWDs.

Keywords: Epilepsy, Absence, Thalamus, Rats, Somatosensory Cortex
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neurophysiology

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Lotfinia A A, Jafarian M, Modarres Mousavi1 M, Hosseini Ravandi H, Karimzadeh F. Role of Laterodorsal Thalamic Nucleus during Absence Seizure Attacks. Shefaye Khatam. 2015; 3 (1) :36-41
URL: http://shefayekhatam.ir/article-1-653-en.html

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Volume 3, Issue 1 (Winter - 2015) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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