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:: Volume 3, Issue 2 (Spring - 2015) ::
Shefaye Khatam 2015, 3(2): 11-18 Back to browse issues page
The Effects of Verapamil and Ethosuximide on the Brain Bioelectrical Activity of WAG/Rij Rats
Mina Sadighi Alvandi , Parviz Shahabi , Ghazaleh Ghamkhari Nejad * , Mina Hosseinpour , Forough Foolad
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran , gh_ghamkhar@yahoo.com
Abstract:   (2374 Views)

Introduction: Synchronization of bioelectrical activities of neurons contributes to the initiation of epileptiform activities occurred during a seizure attack. Absence seizures are characterized by synchronous and symmetric 2.5-4 Hz spike-wave discharges in children under 15 years old. More than half of children with absence epilepsy suffer from cognitive, education, and learning difficulties. The amplitude ratio of the theta and alpha waves is a reliable indicator for measuring of learning difficulties in children. The aim of this study was to evaluate the effect of L- and T-type voltage-dependent calcium channel blockers, verapamil and ethosuximide, on the amplitude of electroencephalogram (EEG) waves in WAG/Rij rats, a genetic animal model of absence epilepsy. Materials and Methods: 18 adult WAG/Rij rats in the age between 4 and 6 months were divided randomly into 3 groups. Using stereotaxic method, cannula was implanted in the peri-oral region of the primary somatosensory cortex for injection of drugs and recording electrodes were placed in the frontal and the occipital cortices. Electroencephalography was recorded 30 minutes before and one hour after drug injection. Results: The power of EEG sub-bands significantly decreased in the first 30 minutes after injection of verapamil and ethosuximide compared to the control group. Conclusion: Our data show that verapamil and ethosuximide can decrease the power of EEG sub-bands. However, they have not noticeable effect on theta to alpha ratio.

Keywords: Epilepsy, Absence, Brain Waves, Rats, Verapamil, Ethosuximide
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neuropharmacology



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Sadighi Alvandi M, Shahabi P, Ghamkhari Nejad G, Hosseinpour M, Foolad F. The Effects of Verapamil and Ethosuximide on the Brain Bioelectrical Activity of WAG/Rij Rats . Shefaye Khatam. 2015; 3 (2) :11-18
URL: http://shefayekhatam.ir/article-1-683-en.html


Volume 3, Issue 2 (Spring - 2015) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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