Introduction: Due to the possible impact of posttraumatic stress disorder (PTSD) on biological markers of cardiovascular responses, it has become an essential part and hallmark of the diagnostic and statistical manual of mental disorders in the Fifth edition-DSM-5. This study aimed to investigate the biomarkers of cardiovascular responses in war veterans with PTSD. Materials and Methods: 34 male war veterans, among veterans with posttraumatic stress disorder in Kermanshah, participated in this cross sectional study on 2014. They were approved by medical committee as patients who suffer from PTSD. The data were collected by PTSD Checklist-Military version (PCL-M). Results: Data indicate that the mean age, the percentage of injury, and the duration that each individual spent in the war were 53.73, 45.72, and 4.07, respectively. The mean scores of systolic blood pressure, diastolic blood pressure, heart rate, and body temperature were 123.72 mm Hg, 82.94 mm Hg, 89, and 36.51°C, respectively. In addition, the Pearson correlation coefficient among the biomarkers of cardiovascular and the total score obtained in the posttraumatic stress disorder checklist was positive and significant. Conclusion: The results indicate the biological markers of cardiovascular responses as a risk factor for cardiovascular diseases in the war veterans with PTSD.