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:: Volume 3 - The Autumn Supplement of Shefaye Khatam 3 - ::
Shefaye Khatam 2015, 3 - The Autumn Supplement of Shefaye Khatam 3 -: 48-48 Back to browse issues page
P21: Is Interleukin-1 Beta Correlated with Intra Cranial Pressure after Traumatic Brain Injury?
Sajad Sahab Negah , Zabihollah Khaksar , Ali Jahanbazi Jahan-Abad * , Arezou Eshaghabadi , Mostafa Modarres Mousavi , Hassan Hossini Ravandi
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran , a.jahanbazi65@yahoo.com
Abstract:   (3521 Views)

Traumatic brain injury is a leading cause of disability and death from injury in the world. The Interleukin-1 (IL-1) is a family of cytokines that act as key mediators of the inflammatory response peripherally and centrally. Based on many studies, researchers found that the IL-1 is the well-known molecule in relation to acute TBI in the models of both focal and diffuse injuries. The IL-1 family includes the closely related agonists IL-1α and IL-1β. Interleukin-1 beta (IL-1β) is a pro-inflammatory cytokine with a key role in the inflammatory response following TBI and studies indicate that attenuation of this cytokine improves behavioral outcomes. IL-1β is measurable in the serum or CSF of healthy individuals. Although changes in IL-1β expression in CSF and serum following injury appear to be small, attempts have been made to correlate IL-1β levels with outcome. It have been reported that in severe brain injury patients, high concentrations of IL-1β in CSF were associated with poor outcome and increased intra cranial pressure.

Keywords: TBI, IL-1β, Intra Cranial Pressure
Full-Text [PDF 176 kb]   (1175 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Sahab Negah S, Khaksar Z, Jahanbazi Jahan-Abad A, Eshaghabadi A, Modarres Mousavi M, Hossini Ravandi H. P21: Is Interleukin-1 Beta Correlated with Intra Cranial Pressure after Traumatic Brain Injury?. Shefaye Khatam 2015; 3 (S3) :48-48
URL: http://shefayekhatam.ir/article-1-865-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 3 - The Autumn Supplement of Shefaye Khatam 3 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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