The Role of Glutamate Receptors, Synaptic Ion Channels, and Trkb Receptor in Learning and Memory
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Ali Jahanbazi Jahan-Abad * , Nasim Shah Hamzei , Leyla Alizadeh |
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran , a.jahanbazi65@yahoo.com |
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Abstract: (5373 Views) |
Introduction: Long-term potentiation (LTP) is a generic term that applies to a form of activity-dependent plasticity that induced by high-frequency or theta burst stimulation and results in enhancement of synaptic transmission. LTP has a key role in learning and memory. Different types of LTP have been observed in distinctive areas of the central nervous system. Hippocampal CA1 area is vital for the formation of long-term memory. Conclusion: Several studies have been shown the importance of signaling pathways in the development of memory and learning. In this review is intended to present an overview of the role of synaptic ion channels, ionotropic and metabotropic glutamate receptors as well as TrkB receptor in LTP formation of learning and memory. |
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Keywords: Long-Term Potentiation, Learning, Memory, Receptors, Glutamate |
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Full-Text [PDF 546 kb]
(6337 Downloads)
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Type of Study: Review --- Open Access, CC-BY-NC |
Subject:
Neurology
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