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:: Volume 3, Issue 4 (Autumn - 2015) ::
Shefaye Khatam 2015, 3(4): 139-150 Back to browse issues page
The Neuroprotective Role of Progesterone in Traumatic Brain Injury; Reduction of Inflammatory Cytokines
Sajad Sahab Negah , Arezou Eshaghabadi , Elham Mohammadzadeh *
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Biology and Anatomical Sciences, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , elhammohammadzadeh85@gmail.com
Abstract:   (1213 Views)

Introduction: Traumatic brain injury (TBI) is one of the leading causes of death of men under the age of 35 that mostly occurs during the road accidents. Current clinical treatments cannot prevent the secondary brain damage induced by cytotoxicity. Progesterone, as a primary sex hormone, is a neuroprotective compound in TBI and stroke. Indeed, progesterone increases anti-oxidant activities, decreases inflammatory factors, and reduces the expression of inflammatory cytokine, which can prevent secondary brain injury and edema. Conclusion: This review focused on the preventive effect of progesterone on secondary brain injury and edema by modulation of inflammatory factors in TBI. Although, the exact mechanism of TBI has not been discovered, studies suggest that this hormone can be a safe treatment for TBI and other neurodegenerative diseases.

Keywords: Brain Injuries, Progesterone, Neuroprotective Agents
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Molecular Neurobiology



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Sahab Negah S, Eshaghabadi A, Mohammadzadeh E. The Neuroprotective Role of Progesterone in Traumatic Brain Injury; Reduction of Inflammatory Cytokines . Shefaye Khatam. 2015; 3 (4) :139-150
URL: http://shefayekhatam.ir/article-1-909-en.html


Volume 3, Issue 4 (Autumn - 2015) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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