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:: Volume 4, Issue 1 (Winter - 2016) ::
Shefaye Khatam 2016, 4(1): 1-6 Back to browse issues page
Effect of Gallic Acid and Endurance Exercise Training on BDNF in a Model of Hippocampal Degeneration
Samaneh Rafiei , Yunes Bazyar , Mohammad Amin Edalatmanesh *
Department of Physiology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran , amin.edalatmanesh@gmail.com
Abstract:   (2588 Views)

Introduction: The aim of this study was to investigate the effect of gallic acid on hippocampal level of brain derivative neurotrophic factor (BDNF) in trimethyltin chloride (TMT)- intoxication rats after eight weeks of endurance training. Materials and Methods: Seventy Sprague-dawley male rats were selected and randomly divided into seven groups, including: (1) Control, (2) Sham, (3) Gallic acid 50, (4) Gallic acid 100, (5) Endurance training (4), (6) Training + Gallic acid 50, and (7) Training + Gallic acid 100. Hippocampal degeneration was induced by TMT (8 mg/kg) in all groups except control animals. During eight weeks, rats of groups 3, 6 and 7 ran on treadmill’s without incline at a speed of 15 to 20 meters per minute for 15 to 30 minutes per session, five times weekly. In addition, groups 4 and 6 were treated with gallic acid (50 mg/kg) and groups 5 and 7 with gallic acid (100 mg/kg) every day for 14 days. Results: The findings showed that hippocampal levels of BDNF in all test groups was significantly higher than sham group. Conclusion: Endurance training and gallic acid as well as the combination of them increase the level of hippocampal BDNF in a model of TMT-intoxication.

Keywords: Hippocampus, Physical Endurance, Gallic Acid, Brain-Derived Neurotrophic Factor
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

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Rafiei S, Bazyar Y, Edalatmanesh M A. Effect of Gallic Acid and Endurance Exercise Training on BDNF in a Model of Hippocampal Degeneration . Shefaye Khatam. 2016; 4 (1) :1-6
URL: http://shefayekhatam.ir/article-1-920-en.html

Volume 4, Issue 1 (Winter - 2016) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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