Introduction: Chronic pain is a healthcare problem worldwide without any appropriate treatment. Effective compatibility with pain requires comprehensive compliance through all aspects of patient's life. Psychological factors are central to the experience of chronic pain and can minimize the restrictive effects of pain. Materials and Methods: Two experimental and control groups, consisting 15 people were selected among patients with chronic pain in Khatam-Alanbia hospital. Kessler K10 distress questionnaire was used in pre-and post-test evaluations. Results: A significant difference was observed in distress levels between experimental and control groups in pre- and post-test evaluation. The mean value of distress in experimental group was lower than control group in post- test evaluation. Conclusion: Cognitive behavioral therapy is an effective treatment in reduction of distress in patients suffering from chronic pain.