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:: Volume 7, Issue 1 (Winter - 2019) ::
Shefaye Khatam 2019, 7(1): 1-12 Back to browse issues page
Effects of Regular and Irregular Deep Brain Stimulation on the Basal Ganglia Dynamics: A Computational Approach
Mojtaba Alavi Seyed, Amin Mirzaei, Reza Ebrahimpour *
Faculty of Computer Engineering, Shahid Rajaee Teacher Training University, Tehran, Iran , rebrahimpour@sru.ac.ir
Abstract:   (966 Views)
Introduction: The basal ganglia are subcortical structures of the brain which are involved in the motor system. One of the common disorders related to malfunctioning of the basal ganglia is Parkinson’s disease (PD). PD is accompanied by strong and permanent beta band oscillations in the basal ganglia. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) in the basal ganglia is known as an approach to reduce pathological beta oscillations in PD and to improve PD-related motor symptoms. Despite the success of this approach, its underlying mechanisms are still unclear. Materials and Methods: In this study, we proposed a computational network model for the cortico-basal ganglia loop based on the model suggested by Terman and colleagues earlier. We modified the network model in the manner that it can generate pathological beta oscillations in the PD state. Then, by applying different DBS scenarios (such as regular and irregular high frequency excitation of STN), we investigated which scenario is able to reduce the pathological beta power more efficiently. Results: Our results show that the network model can generate pathological beta band oscillations similar to what has experimentally been observed in the PD state. Our simulation results indicate that the regular DBS outperforms the irregular DBS, in terms of reducing the PD-related beta oscillations and improving the motor symptoms. Conclusion: Using our simulation results, we conclude that applying regular high frequency DBS on the STN neurons in the basal ganglia can ameliorate PD-related motor deficits better than irregular DBS pulses. This simulation result is experimentally testable. 
Keywords: Basal Ganglia, Subthalamic Nucleus, Deep Brain Stimulation
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience
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Alavi M, Mirzaei A, Ebrahimpour R. Effects of Regular and Irregular Deep Brain Stimulation on the Basal Ganglia Dynamics: A Computational Approach. Shefaye Khatam. 2019; 7 (1) :1-12
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Volume 7, Issue 1 (Winter - 2019) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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