:: Volume 7, Issue 4 (Autumn 2019) ::
Shefaye Khatam 2019, 7(4): 106-121 Back to browse issues page
Effect of Prenatal Stress on Offspring's Learning, Memory and Coping Strategies
Fatemeh Aghighi , Mahmoud Salami , Alireza Talaei *
Physiology Research Center, Ins titute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran , talaei@kaums.ac.ir
Abstract:   (5873 Views)
Introduction: The prenatal stress is a key factor which affects the growth and function of the brain. Several studies have shown that prenatal stress induces deficits in learning and memory of the offspring. The prenatal stress alters the activity of neurotransmitters, such as noradrenaline, dopamine and serotonin, via over-activation of the hypothalamic–pituitary–adrenal axis. In addition, the prenatal stress reduces the values of various hippocampal proteins involved in learning and memory and long-term potentiation, like brain-derived neurotrophic factor, Ca2+/calmodulin dependent protein kinase II, postsynaptic density protein 95, and cAMP response element-binding protein. It seems that exercise, environmental enrichment, and antioxidants could improve learning and memory deficits induced by the prenatal stress in offspring. Conclusion: Interventions to protect the offspring against stress is crucial to preserve their cognitive abilities.
Keywords: Maternal Exposure, Learning, Memory, Neuronal Plasticity
Full-Text [PDF 883 kb]   (2695 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience
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