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:: دوره 11، شماره 4 - ( پاییز 1402 ) ::
دوره 11 شماره 4 صفحات 124-108 برگشت به فهرست نسخه ها
پدیده مهار منتشرشونده: مکانیسم اثر در بیماری‌های التهاب عصبی
آرزو اسحاق آبادی نیاسری ، علی گرجی ، هانیه جلالی*
گروه علوم جانوری، دانشکده علوم زیستی، دانشگاه خوارزمی، تهران، ایران ، jalali@khu.ac.ir
چکیده:   (278 مشاهده)
مقدمه: مهار منتشر‌شونده یک پدیده پاتوفیزیولوژیک است که به صورت موج‌گذرای دپلاریزاسیون نورون‌ها و سلول‌های گلیال دیده می‌شود و منجر به مهار موقتی فعالیت‌های سلول‌های عصبی مغزی می‌شود. در این پدیده به‌دلیل اختلال در توزیع و توازن یون‌ها و آب بین محیط‌های خارج و داخل سلولی یک افزایش کوتاه مدت فعالیت الکتریکی در تحریک‌پذیری سلول‌های عصبی، سپس کاهش شدید این فعالیت‌ها و به‌دنبال آن افزایش تحریک‌پذیری بافت عصبی صورت می‌گیرد. تحقیقات اخیر به نقش این پدیده در ایجاد التهاب در بافت عصبی که می‌تواند زمینه‌ساز بیماری‌های عصبی گردد تاکید دارد. مهار منتشر‌شونده در برخی از بیماری‌های عصبی مانند میگرن با اورا، صرع، فراموشی کلی گذرا و بیماری‌های عروقی مغزی نظیر ایسکمی- انفارکتوس مغزی و خونریزی داخل جمجمه مشاهده می‌شود و به‌نظر می‌رسد در پاتوفیزیولوژی این بیماری‌ها نقش مهمی ایفا می‌کند. لذا درک مکانیسم‌های دخیل در این پدیده می‌تواند به جلوگیری و یا طراحی درمان‌های نوین در بیماری‌های عصبی کمک کند. نتیجه‌گیری: با وجود سال‌ها تحقیق و بررسی و ارائه هزاران گزارش و مقاله در مورد پدیدۀ مهار منتشر شونده، هنوز دلایل اصلی ایجاد این اختلال مشخص نیست و نیاز به بررسی‌های دقیق‌تر و بیشتری دارد. در مقالۀ حاضر آخرین مکانیسم‌های دخیل در پدیدۀ مهار منتشر شونده مرور شده و نقش این پدیده در ایجاد و یا گسترش بیماری‌های عصبی مورد ارزیابی قرار گرفت.
 
واژه‌های کلیدی: مهار منتشر شونده قشری، ضربه‌های مغزی، بیماری‌های التهاب عصبی
متن کامل [PDF 660 kb]   (106 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: تحقیقات پایه در علوم اعصاب
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Eshaghabadi Niasari A, Gorji A, Jalali H. Spreading Depression: Mechanism of Action in Neuroinflammatory Diseases. Shefaye Khatam 2023; 11 (4) :108-124
URL: http://shefayekhatam.ir/article-1-2427-fa.html

اسحاق آبادی نیاسری آرزو، گرجی علی، جلالی هانیه. پدیده مهار منتشرشونده: مکانیسم اثر در بیماری‌های التهاب عصبی. مجله علوم اعصاب شفای خاتم. 1402; 11 (4) :108-124

URL: http://shefayekhatam.ir/article-1-2427-fa.html



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