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:: دوره 11، شماره 4 - ( پاییز 1402 ) ::
دوره 11 شماره 4 صفحات 93-79 برگشت به فهرست نسخه ها
کاربرد فناوری چاپ زیستی سه‌بعدی در درمان ضایعات طناب نخاعی
آرش عبدالملکی ، لیلا تقی زاده مومن ، اسداله اسدی* ، شوکور واسمن اسماعیل
گروه زیست ‌شناسی، دانشکده علوم، دانشگاه محقق اردبیلی، اردبیل، ایران ، asad.asady@gmail.com
چکیده:   (289 مشاهده)
مقدمه: آسیب طناب نخاعی یک بیماری مرتبط با سیستم عصبی مرکزی است که منجر به اختلال در عملکردهای حسی و حرکتی، از دست دادن آکسون، جسم سلولی و پشتیبانی سلول‌های گلیال می‌شود. در حال حاضر، درمان آسیب‌های نخاعی محدود به فیزیوتراپی، کاردرمانی و جراحی است. با این حال، روش‌های درمانی فعلی نمی‌توانند به طور کامل و مؤثر رشته‌های عصبی آسیب دیده را بازسازی کرده و عملکرد عصب را بهبود بخشند. مهندسی بافت عصبی متمرکز بر ساخت داربست‌های بیومیمتیک الهام گرفته از ساختار پیچیده نخاع به همراه سلول‌ها در جهت ترمیم ضایعات نخاعی می‌باشد. در سال‌های اخیر، از روش چاپ زیستی سه‌بعدی برای ساخت مدل‌های زیستی بسیار تخصصی و پیچیده مانند نخاع استفاده شده است. چاپ زیستی با قرار دادن جوهر زیستی بر روی یک بستر به صورت لایه لایه انجام می شود. رویکرد افزودنی چاپ زیستی امکان ساخت مدل‌های بافتی سه بعدی ظریف را با کنترل دقیق بر موقعیت مکانی سلول‌ها فراهم می‌کند. نتیجه‌گیری: استفاده از فناوری چاپ زیستی سه بعدی در زمینه ساخت داربست‌های غنی از سلول و مطالعات درون‌تنی در مدل‌های آسیب طناب نخاعی نشان‌دهنده چشم انداز روشن این فناوری در زمینه درمان ضایعات نخاعی است. با این حال، برای شبیه‌سازی کامل بافت نخاع و بهبود عملکرد عصبی نخاع پس از آسیب، لازم است تحقیقات بیشتری با سلول‌ها، بیومواد و مدل‌های آسیب نخاعی مختلف انجام شود. در مقاله مروری حاضر، به روش چاپ زیستی سه‌بعدی، انواع تکنیک‌های چاپ در مهندسی بافت طناب نخاعی و مطالعات انجام شده در راستای کاربرد چاپ زیستی در درمان ضایعات طناب نخاعی پرداخته شده است.
 
واژه‌های کلیدی: چاپ زیستی، آسیب طناب نخاعی، مهندسی بافت
متن کامل [PDF 944 kb]   (147 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: ترميم عصبي
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Abdolmaleki A, Taghizadeh Momen L, Asadi A, Wasman Smail S. The Application of 3D Bioprinting Technology in the Treatment of Spinal Cord Lesions. Shefaye Khatam 2023; 11 (4) :79-93
URL: http://shefayekhatam.ir/article-1-2428-fa.html

عبدالملکی آرش، تقی زاده مومن لیلا، اسدی اسداله، واسمن اسماعیل شوکور. کاربرد فناوری چاپ زیستی سه‌بعدی در درمان ضایعات طناب نخاعی. مجله علوم اعصاب شفای خاتم. 1402; 11 (4) :79-93

URL: http://shefayekhatam.ir/article-1-2428-fa.html



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مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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