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The Effects of Combined Home-Based Exercise and Olive Oil Supplementation on Interleukin-6 Levels and Quality of Life in Women with Multiple Sclerosis
Zeynab Ghasemi , Raziye Rezaei , Mohammad Fathi *
Department of Physical Education and Sport Sciences, Faculty of Human Sciences, Lorestan university, Khorramabad, Iran , Fathi.m@lu.ac.ir
Abstract:   (14 Views)
Introduction: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by inflammation, demyelination, and axonal damage, affecting patients’ functioning and quality of life. Interleukin-6 (IL-6) is a pro-inflammatory cytokine involved in MS pathogenesis. Exercise and nutritional interventions, including extra-virgin olive oil supplementation, have attracted attention as non-pharmacological strategies. This study aimed to investigate the effects of an eight-week home-based combined aerobic–resistance exercise program accompanied by extra-virgin olive oil supplementation on interleukin-6 (IL-6) levels and quality of life in women with MS. Materials and Methods: This quasi-experimental study used a pretest-posttest design with a control group and included 48 women with relapsing-remitting MS and an EDSS score of 1–4. Participants were randomly assigned to four groups (n = 12 per group): exercise, extra-virgin olive oil supplementation, combined exercise and supplementation, and control. The exercise groups performed home-based combined aerobic-resistance exercise for eight weeks, three sessions per week, with each session lasting 60 minutes. The supplementation group consumed 25 mL of extra virgin olive oil daily, while the combined group received both interventions. IL-6 was assessed using ELISA, and quality of life was evaluated using WHOQOL-BREF .Results: After controlling for baseline values, no significant between-group differences were observed in IL-6 (F=0.263, p=0.852, ηp²=0.019) or quality of life (F=1.507, p=0.227, ηp²=0.102). However, descriptive findings indicated reduced IL-6 and improved quality of life, particularly in the combined group. Baseline values of both variables were significant predictors of their respective post-test values .Conclusion: Eight weeks of home-based combined exercise accompanied by extra-virgin olive oil supplementation was associated with descriptive improvements in IL-6 and quality of life; however, these differences were not statistically significant after adjustment for baseline values. Future studies with larger samples and longer intervention periods are needed to determine whether these findings translate into clinically meaningful effects.
 
Keywords: Cytokines, Dietary Supplements, Resistance Training, Inflammation, Biomarkers
     
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neurophysiology
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