[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
Main Menu
Journal Information::
Articles Archive::
Guide for Authors::
For Reviewers::
Ethical Statements::
Site Facilities::
Contact us::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Copyright Policies




Open Access Policy

This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

:: Volume 9, Issue 1 (Winter 2020) ::
Shefaye Khatam 2020, 9(1): 1-5 Back to browse issues page
Calcium Channel Blockers: New Therapeutic Targets for Alzheimer's Disease
Hooman Bozorgi * , Hamed Darbanian
Department of Pharmacology, Research Center of Physiology and Neurosciences, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran , hoomanbozorgi@semums.ac.ir
Abstract:   (3616 Views)
Introduction: Alzheimer disease (AD) is the most common type of dementia in the elderly. Memory impairment usually occurs gradually and progressively. AD has not only been associated with decreased cerebral acetylcholine concentration, oxidative stress, and beta-amyloid protein deposition, but more recent studies have shown that neurodegeneration induced by disturbance of the intracellular calcium homeostasis is also involved in the pathophysiology of the disease. It has been reported that calcium channel blockers (CCBs) have beneficial effects in different models of memory impairment. Here, we review and discuss the effects of CCBs, especially N-types, as novel agents that have effects on memory deficits in animal models of AD. on contrary to the L-type calcium channels, which are presented in the other organs in addition to nerve cells, N-type calcium channels are commonly located on the neurons. The main advantage of N-type CCBs is their lower side effects than other CCBs. Conclusion: Targeting the N-type CCBs may contribute to the new strategies for the treatment of AD.
Keywords: Alzheimer Disease, Calcium Channel Blockers, Therapeutics
Full-Text [PDF 397 kb]   (1543 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Neuropharmacology
1. Feuerstein G, Hunter J, Barone FC. Calcium channel blockers and neuroprotection. Emerg Strateg Neuroprotection. 2013; 129-50. [DOI:10.1007/978-1-4684-6796-3_8]
2. Nimmrich V, Eckert A. Calcium channel blockers and dementia. Br J Pharmacol. 2013; 169: 1203-10. [DOI:10.1111/bph.12240]
3. Chiozzi P, Sarti AC, Sanz JM, Giuliani AL, Adinolfi E, Vultaggio-Poma V, et al. Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine. Sci Rep. 2019; 9: 6475. [DOI:10.1038/s41598-019-42931-2]
4. Heale R. Dementia care and treatment issues. Evid Based Nurs. 2020; 23: 40-2. [DOI:10.1136/ebnurs-2020-103260]
5. Freir DB, Costello DA, Herron CE. Aβ25-35-induced depression of long-term potentiation in area CA1 in vivo and in vitro is attenuated by verapamil. J Neurophysiol. 2003; 89: 3061-9. [DOI:10.1152/jn.00992.2002]
6. Schmidtko A, Lötsch J, Freynhagen R. Ziconotide for treatment of severe chronic pain. Lancet. 2010; 375: 1569-77. [DOI:10.1016/S0140-6736(10)60354-6]
7. Skov MJ, Beck JC, de Kater AW. Nonclinical safety of ziconotide: an intrathecal analgesic of a new pharmaceutical class. Int J Toxicol. 2007; 26: 411-21. [DOI:10.1080/10915810701582970]
8. Bozorgi H, Jahanian-Najafabadi A, Rabbani. The effect of intrathecal administration of the neuronal N-type calcium channels antagonist, ω-conotoxin MVIIA, on attenuating the spontaneous and naloxone-precipitated morphine withdrawal in rats. Toxin Rev. 2016; 35: 33-7. [DOI:10.1080/15569543.2016.1181657]
9. Bozorgi H, Jahanian-Najafabadi A, Rabbani M. Effect of N-type calcium channel blocker Ziconotide on memory in rats following morphine withdrawal. Online J Vet Res. 2016; 20: 335-44.
10. Bozorgi H, Motaghi E, Zamani M, Ghavimi R. Neuronal calcium channels blocker, ziconotide (ɷ-conotoxin MVIIA), reverses morphine withdrawal-induced memory impairments via alteration in hippocampal NMDA receptor expression in rats. Toxin Rev. 2018; 38: 1-10. [DOI:10.1080/15569543.2018.1525402]
11. Bozorgi H, Budde T, Nankali M. Antidepressant-like and memory-enhancing effects of the N-type calcium channel blocker, ziconotide in rats. Behav Brain Res. 2020; 390. [DOI:10.1016/j.bbr.2020.112647]
12. Deutschenbaur L, Beck J, Kiyhankhadiv A, Mühlhauser M, Borgwardt S, Walter M, et al. Role of calcium, glutamate and NMDA in major depression and therapeutic application. Prog Neuropsychopharmacol Biol Psychiatry. 2016; 64: 325-33. [DOI:10.1016/j.pnpbp.2015.02.015]
13. Hannon HE, Atchison WD. Omega-Conotoxins as Experimental Tools and Therapeutics in Pain Management. Mar Drugs. 2013; 11: 680-99. [DOI:10.3390/md11030680]

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Bozorgi H, Darbanian H. Calcium Channel Blockers: New Therapeutic Targets for Alzheimer's Disease. Shefaye Khatam 2020; 9 (1) :1-5
URL: http://shefayekhatam.ir/article-1-2059-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 9, Issue 1 (Winter 2020) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.05 seconds with 45 queries by YEKTAWEB 4657