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:: دوره 11، شماره 1 - ( زمستان 1401 ) ::
دوره 11 شماره 1 صفحات 132-119 برگشت به فهرست نسخه ها
نقش میکرو RNAها در پاتوژنز اسکیزوفرنی
زهرا قاسم زاده ، صدیقه خانجانی جلودار ، فرزانه نظری سرنجه* ، نرجس لطفی قادیکلایی
گروه زیست شناسی، دانشگاه پیام نور، تهران، ایران ، nazari_farzaneh@yahoo.com
چکیده:   (739 مشاهده)
مقدمه: MicroRNAها (میکروRNAها) مولکول‌های RNA کوچک و غیر کد کننده‌ای هستند که به‌عنوان تنظیم کننده‏‌های بسیار قوی بیان ژن پس از رونویسی عمل می‏ کنند. در دهه‏ های گذشته مشخص شده است که میکرو RNAها رشد و عملکرد مغز را تحت تاثیر قرار می‏ دهند. اسکیزوفرنی یک اختلال روانپزشکی پیچیده و شدید است که عوامل خطر ژنتیکی و محیطی در بروز آن نقش دارند. مطالعات اخیر نشان داده است که اختلال در بیان میکرو RNAها در پاتوژنز اسکیزوفرنی نقش دارد. نتیجه‌گیری: شناسایی میکرو RNAهای مرتبط با SCZ می ‏توانند به‌عنوان نشانگرهای زیستی بالقوه‏ای در تشخیص و درمان های کارآمدتر اسکیزوفرنی مورد توجه قرار گیرند. در مقاله حاضر، مروری بر یافته‌های اخیر از اختلال در بیان میکرو RNAهای مرتبط با SCZ ارائه شده است.
واژه‌های کلیدی: میکروRNA، اسکیزوفرنی، نشانگرهای زیستی
متن کامل [PDF 1482 kb]   (820 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: تحقیقات پایه در علوم اعصاب
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Ghasemzadeh Z, khanjani-Jelodar S, Nazari-Serenjeh F, Lotfi Ghadikolaii N. The Role of microRNA in the Pathogenesis of Schizophrenia. Shefaye Khatam 2022; 11 (1) :119-132
URL: http://shefayekhatam.ir/article-1-2320-fa.html

قاسم زاده زهرا، خانجانی جلودار صدیقه، نظری سرنجه فرزانه، لطفی قادیکلایی نرجس. نقش میکرو RNAها در پاتوژنز اسکیزوفرنی. مجله علوم اعصاب شفای خاتم. 1401; 11 (1) :119-132

URL: http://shefayekhatam.ir/article-1-2320-fa.html



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