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:: Volume 11, Issue 3 (Summer 2023) ::
Shefaye Khatam 2023, 11(3): 95-109 Back to browse issues page
An Investigation into the Effects of Water- and Fat-Soluble Vitamins in Alzheimer's and Parkinson's Diseases
Mohammad Shahverdi , Zahra Sourani , Marzieh Sargolzaie , Mostafa Modarres Mousavi , Behnam Bakhtiari moghadam , Sadegh Shirian *
Shiraz Molecular Pathology Research Center, Dr Daneshbod Pathology Lab, Shiraz, Iran , Shirian85@gmail.com
Abstract:   (495 Views)
Introduction: Neurodegenerative diseases (ND) cause several disruptions in the neuronal function in the brain, resulting in cognitive disorders as well as motor neuron disabilities. Although several factors contribute to the development of these diseases, nutrients could play an important role in their pathogenesis. Nutritional deficiencies or imbalances in vitamins regulation may influence neurological metabolism and lead to abnormal functions in the brain, such as oxidative stress production, mitochondrial dysfunction, and protein accumulation (Synuclein, β amyloid plaques). This may eventually lead to ND. Water- and fat-soluble vitamins not only may prevent Parkinson's and Alzheimer's diseases but also have therapeutic effects on these diseases via their antioxidant and anti-inflammatory properties. However, some studies indicate that vitamin function does not influence on prevention of ND. Conclusion: Regarding to neurological protection role of water- and fat-soluble vitamins, in this review article, we have summarized the role of the neuroprotective effects of vitamins on ND.
Keywords: Vitamins, Alzheimer Disease, Parkinson Disease, Neurodegenerative Diseases
Full-Text [PDF 555 kb]   (210 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience
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Shahverdi M, Sourani Z, Sargolzaie M, Modarres Mousavi M, Bakhtiari moghadam B, Shirian S. An Investigation into the Effects of Water- and Fat-Soluble Vitamins in Alzheimer's and Parkinson's Diseases. Shefaye Khatam 2023; 11 (3) :95-109
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مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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