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Volume 12, Issue 1 (Winter 2023) |
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Use of Nanoparticles by Overcoming the Blood-Brain Barrier in the Treatment of Central Nervous System Diseases
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Arash Abdolmaleki *   , Mehdi Tamjid , Fereshteh Ashrafiyan Nansa , Fatemeh Golivand , Zahra Chavoshi Lahrod , Niloufar Bahari , Shukur Wasman Smail , Zhikal Omar Khudhur |
| Department of Bioinformatics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran , abdolmalekiarash1364@gmail.com |
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Abstract: (1712 Views) |
Introduction: The brain is the most complex and evolved human organ, so protecting its function is a vital issue. The blood-brain barrier formed by the microvascular system of the brain is a membrane strip that separates the blood from the extracellular compartment of the brain in the central nervous system of most vertebrates. The blood-brain barrier is a single layer of endothelial cells that consists of five parts: pericytes, astrocytes, neurons, basement membrane, and connective tissues. The blood-brain barrier is a major barrier to drug delivery to the brain. To effectively release drugs into the brain, various methods have been developed. Among them, drug delivery with nanoparticles has many advantages, including non-invasiveness, cost-effectiveness, better biodegradability, and long-term stability. Conclusion: Investigating the structure and function of the blood-brain barrier, as well as the evaluation of various systems affecting this structure, especially the use of nanoparticles, can play an important role in helping to treat central nervous system diseases.
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| Keywords: Nanoparticles, Blood-Brain Barrier, Central Nervous System |
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Full-Text [PDF 764 kb]
(579 Downloads)
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Type of Study: Review --- Open Access, CC-BY-NC |
Subject:
Neurophysiology
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abdolmaleki A, Tamjid M, Ashrafiyan Nansa F, Golivand F, chavoshi Lahrod Z, Bahari N, et al . Use of Nanoparticles by Overcoming the Blood-Brain Barrier in the Treatment of Central Nervous System Diseases. Shefaye Khatam 2023; 12 (1) :85-93 URL: http://shefayekhatam.ir/article-1-2408-en.html
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