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Volume 12, Issue 2 (Spring 2024) |
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The Role of Exosomes in the Pathogenesis, Diagnosis, and Treatment of Parkinson's and Alzheimer's Diseases
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Hami Reza Moradi   , Sahar Abdollahinezhad , Sohrab Heydarian * |
| Department of Veterinary, Agriculture Faculty, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran , drsohrab.hey@gmail.com |
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Abstract: (1124 Views) |
| Introduction: Parkinson's and Alzheimer's diseases are two common neurodegenerative diseases whose etiology remains largely unknown. These two diseases share similar pathogenesis features, including the progressive loss of specific neurons and the accumulation of deposited proteins. Exosomes, characterized by a lipid bilayer structure akin to that of the cell membrane, originate from various cells throughout the body and can readily traverse different biological membranes, such as the blood-brain barrier. Exosomes are important for the transfer of mediators and information between cells. Therefore, they can play a vital role in the normal and pathological conditions of the brain, including neurodegenerative disorders such as Parkinson’s disease and Alzheimer's disease. This article reviews the role and application of exosomes in the pathogenesis and treatment of Parkinson's and Alzheimer's diseases. Conclusion: The structure and biogenesis of exosomes may play crucial roles in both the diagnosis and progression of neurodegenerative diseases. Moreover, understanding the complex mechanisms governing exosome formation and composition in pathological conditions could offer valuable insights into the underlying pathophysiology of Parkinson's and Alzheimer's diseases. |
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| Keywords: Neurodegenerative Diseases, Blood-Brain Barrier, Central Nervous System, Cell Membrane |
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Full-Text [PDF 988 kb]
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Type of Study: Review --- Open Access, CC-BY-NC |
Subject:
Neurophysiology
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| References |
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Moradi H R, Abdollahinezhad S, Heydarian S. The Role of Exosomes in the Pathogenesis, Diagnosis, and Treatment of Parkinson's and Alzheimer's Diseases. Shefaye Khatam 2024; 12 (2) :87-101 URL: http://shefayekhatam.ir/article-1-2451-en.html
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