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Volume 12, Issue 4 (Autumn 2024) |
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Preventive Effects of Endurance and Cognitive-Motor Training on TREM2 Expression and IL-33 Levels in Vascular Dementia Rats
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Zahra Margani   , Najmeh. A Shojaeian * |
| Department of Sports Sciences, Faculty of Humanities, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran , nshojaeian@yahoo.com |
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Abstract: (425 Views) |
Introduction: Vascular dementia (VaD) is a cognitive impairment that affects the expression of triggering receptor expressed on myeloid cells 2 (TREM2) and interleukin 33 (IL-33). The present study aimed to investigate the preventive effect of endurance and cognitive-motor dual-task training on the TREM2 and IL-33 expression in rats with VaD. Materials and Methods: Forty middle-aged male Wistar rats were randomly assigned to four groups: healthy control, dementia, endurance training + dementia, and dual cognitive-motor task + dementia. The rats in the endurance training group underwent running exercises, while the cognitive-motor dual-task group participated in the Morris water maze for 8 weeks. Following the interventions and the creation of a vascular dementia model through a 30-minute common carotid artery occlusion, blood samples were collected. IL-33 serum levels were measured using the ELISA method, and TREM2 expression was assessed by Western blotting after extracting the hippocampus. Results: The results show that both training methods significantly affected the levels of TREM2 and IL-33. TREM2 levels were significantly higher in both exercise groups compared to the control group and significantly lower compared to the dementia group. Furthermore, IL-33 levels were significantly higher in both exercise groups compared to the control group, with a significant difference observed between the control and dementia groups. Conclusion: Endurance and cognitive-motor dual-task training appear to help maintain appropriate concentrations of TREM2, potentially preventing cognitive and functional decline associated with vVaD. However, no significant difference in IL-33 levels was found between the exercise and dementia groups, highlighting the need for further research on the type, intensity, and impact of exercise on this variable.
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| Keywords: Exercise, Receptors, Immunologic, Interleukins, Neurodegenerative Diseases |
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Full-Text [PDF 1025 kb]
(176 Downloads)
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Type of Study: Research --- Open Access, CC-BY-NC |
Subject:
Neurophysiology
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Margani Z, Shojaeian N A. Preventive Effects of Endurance and Cognitive-Motor Training on TREM2 Expression and IL-33 Levels in Vascular Dementia Rats. Shefaye Khatam 2024; 12 (4) :22-32 URL: http://shefayekhatam.ir/article-1-2541-en.html
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