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:: Volume 13, Issue 1 (Winter 2024) ::
Shefaye Khatam 2024, 13(1): 63-73 Back to browse issues page
From Cognitive Systems to Alzheimer's Disease: The Role of Computational Modeling
Elias Mazrooei * , Seyyed Ali Zendehbad , Shahryar Salmani Bajestani
Department of Biomedical Engineering, Khavaran Institute of Higher Education, Mashhad, Iran , elias_mazrooei@yahoo.com
Abstract:   (418 Views)
Introduction: Computational modeling plays a pivotal role in bridging the gap between cognitive neuroscience and clinical neurology, particularly in the context of neurodegenerative diseases like Alzheimer's disease (AD). This study explores the application of computational models to understand cognitive systems and the pathological processes leading to cognitive decline in AD. Materials and Methods: We proposed a set of computational approaches, including neural networks and dynamical systems modeling, to simulate neural activity, synaptic plasticity, and interactions between genetic and environmental factors. Data integration from neuroimaging, genomics, and behavioral studies was crucial in enhancing the accuracy and predictive capabilities of these models. Results: The computational models provided significant insights into the mechanisms of cognition, memory formation, and their deterioration in AD. Our models identified potential biomarkers and informed strategies for therapeutic intervention, demonstrating the importance of a multi-disciplinary approach to understanding and treating cognitive decline. Conclusion: Computational modeling is essential for promoting our understanding of AD and other cognitive disorders. Future research should focus on refining these models and fostering greater interdisciplinary collaboration to develop more accurate and comprehensive simulations.
 
Keywords: Models, Biological, Brain Mapping, Cognitive Science, Dementia, Image Processing, Computer, Assisted
Full-Text [PDF 1290 kb]   (122 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Cognitive Neuroscience
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mazrooei E, Zendehbad S A, Salmani Bajestani S. From Cognitive Systems to Alzheimer's Disease: The Role of Computational Modeling. Shefaye Khatam 2024; 13 (1) :63-73
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Volume 13, Issue 1 (Winter 2024) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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