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Protective Effects of DNA Vaccine Encoding Glycoprotein D-1 of Herpes Simplex Virus Type 1 on Latency Rate in Trigeminal Ganglia
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Amir Ghaemi *   , Hoorieh Soleimanjahi |
| Department of Biotechnology, Golestan University of Medical Sciences, Gorgan, Iran. , ghaem_amir@yahoo.com |
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Abstract: (14128 Views) |
| Introduction: Herpes simplex encephalitis (HSE) is a rare but very serious disorder caused by herpes simplex type 1 virus (HSV-1). Following primary HSV-1 infection, viral latency develops in the trigeminal ganglia (TG). Therefore, prevention from primary HSV -1 infection and subsequent latency establishment is an important feature for vaccine development. Materials & Methods: We evaluate efficacy of DNA vaccine encoding Glycoprotein D-1 (gD-1) gene of HSV-1 against lethal ocularly challenge of TCID 5 × 105 plaque-forming units (pfu) per eye of wild HSV-1 versus negative control groups. Results: The data demonstrated protective effects of DNA vaccine encoding Herpes simplex virus Glycoprotein D gene on latency rate in TG and mortality rate. Conclusion: These results indicated that immunization with g D-1 DNA vaccine is a promising approach for eliciting a protective immunity against a HSV-1 lethal ocular challenge. |
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| Keywords: Herpes Simplex Virus Type-1, DNA Vaccine, Trigeminal Ganglion |
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Full-Text [PDF 1068 kb]
(2883 Downloads)
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Type of Study: Research --- Open Access, CC-BY-NC |
Subject:
Neuropharmacology
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