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Genetics and Prognosis of Brain Trauma
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Fatemeh Mahmoudi *   , Hamed Nasri , Milad Shademan |
| a. Razavi Neuroscience Research Center, Razavi Hospital, Mashhad, Iran. b. Shahinfar Medical University, Islamic Azad University, Mashhad, Iran. , fateme.mahmudi@yahoo.com |
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Abstract: (13876 Views) |
| Introduction:
Several genes affect the prognosis of traumatic brain injury. Most studies have been conducted
on E apolipoprotein (APOE). APOE may have beneficial effects in coma recovery and reducing
the risk of seizures after trauma. However, allele E4 of APOE is associated with accumulation of amyloid,
which causes amyloid angiopathy and extensive intracranial hematoma. Prognosis of traumatic brain
injury depends on underlying factors, such as APOE, amyloid deposition, cytoskeletal rupture, diss cholinergic
function, oxidative stress and the ability of the central nervous system to response to the injury.
There is a little research on the effects of genes on the brain injury. DRD2 and COMT genes related to
dopamine function in cognitive processes in the frontal lobes are involved.Inflammation also plays an important
role in the pathophysiology of traumatic brain injury and is controlled by the gene IL. Apoptosis
after traumatic brain injury is also regulated by the P53 gene. Converting enzyme gene through self-regulation
mechanism of cerebral blood flow affect the prognosis of cerebral trauma. CACNA1A gene with
its effect on calcium channels and its effect on prevention of brain edema affects the prognosis of brain
trauma. Neprilysin gene causes a protease that plays an important role in the degradation of amyloid β
protein and delayed plaque formation.
Conclusion:
It seems that genetic factors may play an important
role on the prognosis of brain injury. Further studies will be clarified this role in details. |
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| Keywords: Genetics, Brain Injury, APOE, Apoptosis, P53 |
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Full-Text [PDF 2693 kb]
(2823 Downloads)
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Type of Study: Review --- Open Access, CC-BY-NC |
Subject:
Basic research in Neuroscience
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