The Role of Dopamine Receptors during Brain Development
|
Sajad Sahab Negah , Zabihollah Khaksar , Hadi Kazemi , Hadi Aligholi , Maryam Safahani , Mostafa Modarres Mousavi , Shahin Mohammad Sadeghi *  |
Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , drshmsadeghi@gmail.com |
|
Abstract: (11002 Views) |
Introduction: Brain development requires a complex interplay of genetic and environmental factors. Disruption of these elements can affect neuronal structure, function, or connectivity and can alter developmental trajectory. Neurotransmitters and neuromodulators, such as dopamine, participate in a wide range of behavioral and cognitive functions in the adult brain. Dopamine-mediated signaling plays a fundamental neurodevelopmental role in forebrain differentiation and circuit formation. In addition, D1 and D2 dopaminergic receptors activation influences neuronal proliferation, migration and differentiation. Conclusion: As dopamine receptors affect the developing brain and play an essential role in adult brain, better understanding of the role of these receptors in different regions of the developing brain can be helpful for treatment of brain developmental disorders. |
|
Keywords: Dopamine, Growth and Development, Brain |
|
Full-Text [PDF 713 kb]
(10669 Downloads)
|
Type of Study: Review --- Open Access, CC-BY-NC |
Subject:
Molecular Neurobiology
|
|
|
|