Introduction: Systemic inflammatory response occurs after ischemic events in stroke and is responsible for thrombosis progression. In this study, we are intended to evaluate association of C- Reactive Protein (CRP) as an inflammatory marker with acute cerebral ischemic attack variables, risk factors and mortality. Materials & Methods: 162 patients with acute ischemic stroke were enrolled in the study. Medical history was asked and physical examination was performed. Then venous blood samples were drawn from all of the patients at end of the first day. Results: Our results showed that association between high sensitive CRP (hsCRP) and early mortality in the patients with acute CVA was significant. 10% of patients were died within a week after the stroke onset. mean of CRP in died patients was 8.9±7 mg/dl and in survived patients was 2.2±5 mg/dl (p=0.0001). After multivariate analysis and adjusting variables for sex, age, history of heart disease, NIHSS Score and TOAST, we found hsCRP as an independent factor in predicting early onset mortality. Conclusion: This study shows that hsCRP has a direct association with mortality within the first week after stroke and measuring hsCRP within the first hours after stroke may play an important role in determining of patients´ mortality risk.