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The Effect of MK-801 on Memory after Induction of Repetitive Spreading Depression in the Juvenile Rat
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Babak Khodaie   , Ahmad Ali Lotfinia , Mahmoud Lotfinia , Milad Ahmadi , Maryam Jafarian * |
| a. Shefa Neuroscience Research Center, Tehran, Iran. b. School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. , jafarian.m34@gmail.com |
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Abstract: (11101 Views) |
| Introduction: The term cortical spreading depolarization (CSD) describes a wave of mass neuronal depolarization linked with ionic distribution and cellular swelling. Glutamate release following cell depolarization in extracellular space is a major event in this phenomenon. The hippocampus is widely accepted to play a pivotal role in memory. The aim of the present study was to evaluate the role of glutamate N-methyl-D-aspartate (NMDA) sub receptor on SD-induced memory deficits in rats. Materials and Methods: 36 juvenile Wistar rat were used to investigate the role of repetitive SD induction on memory performance by T-Maze test. We have investigated the role of MK-801, a NMDA receptor blocker, on the memory retrieval by the same test. Results: Behavioral assessments showed that memory retrieval significantly impaired following by the repetitive SD induction. However, application of MK-801 improved the memory deficits induced by the repetitive SD. Conclusion: Our data suggested that NMDA receptors may play a critical role on protection of memory in SD related disorders. |
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| Keywords: Cortical Spreading Depression, Hippocampus, Memory, Brain |
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Full-Text [PDF 2184 kb]
(2503 Downloads)
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Type of Study: Research --- Open Access, CC-BY-NC |
Subject:
Neurophysiopathology
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