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:: Volume 2 - The Autumn Supplement of Shefaye Khatam 3 - ::
Shefaye Khatam 2014, 2 - The Autumn Supplement of Shefaye Khatam 3 -: 94-94 Back to browse issues page
P44: Combination Therapies after Traumatic Brain Injury by Bumetanide and Dexamethasone Administration a Hypothesis Study
Hassan Hosseini Ravandi , Milad Ahmadi * , Babak Khodaie , Ahmad Ali Lotfinia , Mahmoud Lotfinia
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. , Pmiladz@gmail.com
Abstract:   (5200 Views)
Traumatic brain injury (TBI) initiates a cascade of numerous pathophysiological events that evolve over time. Despite the complexity of TBI, research aimed at therapy development has almost exclusively focused on single therapies, all of which have failed in multicenter clinical trials. A variety of brain insults, including traumatic brain injury, encephalitis, stroke, and status epilepticus (SE), have the potential to induce the development of epilepsy, particularly temporal lobe epilepsy (TLE) in humans and rodent models of TLE. The mechanisms underlying this process, which is termed epileptogenesis, are only incompletely understood, but include inflammation, neurodegeneration, blood–brain barrier disruption, alterations in expression and function of diverse receptors and ion channels, and development of hyperexcitability of neurons and neuronal circuits. The goal of the present study was to directly address this hypothesis by treating rats with the NKCC1 inhibitor bumetanide after a TBI. For the present experiments, Wistar rats, weighing 200–230 gr must be used. As previous studies on animal model of TBI treat by co-administration of dose dependent bumetanide and dexamethasone. Predict result: the result may show dexamethasone can inhibition second injury also combination of these two drugs may have reduction and inhibition of neural injury and inflammatory process. Co-administration of dose dependent bumetanide and Dexamethasone may have therapeutic role in traumatic brain injury.
Keywords: Traumatic Brain Injury, Bumetanide, Dexamethasone
Full-Text [PDF 191 kb]   (1558 Downloads)    
Type of Study: Hypothesis --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Hosseini Ravandi H, Ahmadi M, Khodaie B, Lotfinia A A, Lotfinia M. P44: Combination Therapies after Traumatic Brain Injury by Bumetanide and Dexamethasone Administration a Hypothesis Study. Shefaye Khatam 2014; 2 (S3) :94-94
URL: http://shefayekhatam.ir/article-1-553-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 2 - The Autumn Supplement of Shefaye Khatam 3 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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