Introduction: Obesity is one of the most prevalent diet-related problems and increases the risk for diabetes mellitus, hypertension, atherosclerosis, and dyslipidemia. Cardiovascular diseases are one of the major of morbidity and mortality in people with a spinal cord injury (SCI). Increased fat mass has also been identified as an important risk factor in chronic SCI and weight management is recommended as an important preventive strategy of cardiovascular disease. The aim of this study is to determine the prevalence of overweight and obesity in people with SCI. Materials and Methods: An observational analytic cross sectional study was done on 850 SCI patients registered in Khatam Alanbia Hospital, Tehran, Iran, from 2008 to 2013. These data are included age, sex, height, weight, duration of SCI, and the level of SCI. The body mass index (BMI) was subsequently calculated for each patient and the prevalence of overweight and obesity were determined. Results: Of the 850 patients, 833 patients were male and 17 were female. In all, 50.2% of patients had a normal BMI and 7.6% of patients were undernourished. The prevalence of overweight and obesity were 32.1% and 10%, respectively. There was a significant relation between age and body mass index but there was no significant correlation between the level of injury and body mass index. Conclusion: Prevalence of overweight and obesity are high in people with SCI and there is a significant positive correlation between BMI and age.