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Volume 3 - The Summer Supplement of Shefaye Khatam 2 -
Shefa Neuroscience Research Center, Khatam Alanbia Hospital Tehran, Iran , a.jahanbazi65@yahoo.com
Abstract: (4278 Views)
Long-term potentiation (LTP) is a reflection of synaptic plasticity that has an important role in learning and memory. LTP is a long-lasting increase of synaptic activity due to enhancement of excitatory synaptic transmission after a high-frequency train of electrical stimulation. The role of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in excitatory synaptic transmission and LTP formation uncovered over recent decades. The activity regulation of AMPA receptors (AMPARs) has a significant role in the LTP induction. AMPARs are homomeric or heteromeric receptors combined of four subunits GLUA1 to GLUA4. GluR1 have a critical role in LTP formation in the CA1 region of hippocampus and is necessitated for synaptic delivery of AMPA receptors.
Jahanbazi Jahan-Abad A, Hosseini Ravandi H. P24: The Role of Ionotropic Glutamate Receptors in the Induction of LTP. Shefaye Khatam 2015; 3 (S2) :42-42 URL: http://shefayekhatam.ir/article-1-814-en.html
