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:: دوره 7، شماره 3 - ( تابستان 1398 ) ::
دوره 7 شماره 3 صفحات 73-61 برگشت به فهرست نسخه ها
مروری بر تأثیر ملاتونین بر بیماری‌های سیستم عصبی
زینب خلیلی ، پرستو براتی دوم ، مرضیه درویشی* ، خدیجه ابدال
گروه علوم تشریح، دانشکده علوم پزشکی، دانشگاه علوم پزشکی ایلام، ایلام، ایران
چکیده:   (7247 مشاهده)
مقدمه: ملاتونین هورمونی است که از غده پینه‌آل ترشح شده و نقش مهمی در تنظیم عملکردهای مغز ایفاء می‌کند. این هورمون با فعالیت آنتی اکسیدانی موجب حمایت بدن در برابر عوامل آسیب‌رسان داخلی و خارجی می‌گردد. ملاتونین با حفظ هوموستازی میتوکندری تولید رادیکال‌های آزاد را کاهش می‌دهد و به سنتز ATP در میتوکندری‌ کمک می‌کند. کاهش ملاتونین با افزایش سن یکی از فرضیه های مطرح شده در زمینه توجیه افزایش بروز اختلالات عصبی است. عوامل مختلفی در تنظیم و تولید ملاتونین نقش دارند. این هورمون به‌عنوان یک عامل محافظتی عصبی در برابر برخی اختلالات عصبی از قبیل بیماری آلزایمر، بیماری پارکینسون، افسردگی و میگرن عمل می‌کند. نتیجه‌گیری: با توجه به اثرات مثبت بر سیستم عصبی، خواص غیر سمی پس از مصرف طولانی‌مدت و نبود عوارض جانبی، ملاتونین می‌تواند یک ترکیب مناسب برای درمان برخی بیماری‌های عصبی باشد.
واژه‌های کلیدی: ملاتونین، افسردگی، بیماری‌های سیستم عصبی
متن کامل [PDF 1314 kb]   (8386 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: نوروبيولوژي مولكولي
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Khalili Z, Barati Dowom P, Darvishi M, Abdal K. An Overview of the Effects of Melatonin on Nervous System Diseases. Shefaye Khatam 2019; 7 (3) :61-73
URL: http://shefayekhatam.ir/article-1-1940-fa.html

خلیلی زینب، براتی دوم پرستو، درویشی مرضیه، ابدال خدیجه. مروری بر تأثیر ملاتونین بر بیماری‌های سیستم عصبی. مجله علوم اعصاب شفای خاتم. 1398; 7 (3) :61-73

URL: http://shefayekhatam.ir/article-1-1940-fa.html



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Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
دوره 7، شماره 3 - ( تابستان 1398 ) برگشت به فهرست نسخه ها
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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