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Volume 8, Issue 2 (Spring 2020) |
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Pathogenic and Therapeutic Role of Micrornas in Glioblastoma Multiforme
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Maliheh Babazadeh   , Mohammad Reza Zolfaghary , Sadegh Shirian , Amir Ghaemi * |
| Department of Influenza and other Respiratory Viruses, Pasteur Institute of Iran, Tehran, Iran , ghaem_amir@yahoo.com |
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Abstract: (3634 Views) |
| Introduction: Glioblastoma multiforme (GBM) is a severe type of brain tumors with very poor prognosis and a median survival time of about 15 months. To identify new biomarkers and therapeutic approaches, novel methods are crucial to treat GBM, based on the biological and molecular nature of these tumors. Recently, microRNAs (miRNAs) have been extensively used with the aim of developing accurate molecular therapies, due to their emerging role in the regulation of cancer-related genes. miRNAs, a class of small non-coding RNA species, have vital roles across various biological processes, which may serve as diagnostic and prognostic tools in GBM. Conclusion: This review indicated that miRNAs signatures could be used for developing new molecular therapies to enhance the survival of GBM patients. On the other hand, miRNAs regulate a wide range of cellular functions, allowing them to modulate many pathways critical to GBM progression, including proliferation, cell death, metastasis, angiogenesis, and drug resistance. |
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| Keywords: Glioblastoma, MicroRNAs, Cell Death |
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Full-Text [PDF 1053 kb]
(1522 Downloads)
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Type of Study: Review --- Open Access, CC-BY-NC |
Subject:
Basic research in Neuroscience
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