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دوره 8 شماره 4 صفحات 90-102 برگشت به فهرست نسخه ها
نقش کلیدی ماکروفاژها و مونوسیت‌ها در آسیب نخاعی؛ توسعه رویکردهای درمانی جدید
موسی جاودانی*، ابوالفضل برزگر بفروئی
گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه شهرکرد، شهرکرد، ایران ، Javdani59@gmail.com
چکیده:   (151 مشاهده)
مقدمه: آسیب نخاعی، به واسطه فعال شدن پاسخ‌های ایمنی ذاتی سبب التهاب می‌شود. فرایند آسیب‌های نخاعی ثانویه شامل آپوپتوز الیگودندروسیت‌ها، تخریب غلاف میلین، انحطاط آکسونی و مرگ سلول‌های عصبی است. میکرومحیط التهابی ایجاد شده ناشی از آسیب‌های نخاعی، ترمیم و بهبود عصبی را متأثر می‌کند. در آسیب نخاعی فعال شدن ماکروفاژها، تجمع و التهاب پایا روی می‌دهد. ماکروفاژها، سلول‌های هتروژنی با عملکردهای متغیر و گسترده هستند که برخی از فنوتیپ‌های آن نقشی مهم در کاهش بهبود پس از رخداد آسیب عصبی دارند. بعد از رخداد آسیب عصبی، میکروگلیاهای مقیم و محیطی مشتق شده از سلول‌های ایمنی در فرایندهای التهابی و فرا تنظیمی سایتوکاین‌های التهابی مشارکت می‌کنند. از دیگر بحث‌های مهم می‌توان به نقش مونوسیت‌ها، به‌عنوان منبع ماکروفاژها، در فرایند آسیب نخاعی اشاره کرد. درک نقش و عملکرد این سلول‌ها راهبردهای درمانی نوین را می‌تواند رهنمود باشد. نتیجه‌گیری: نفوذ سریع لوکوسیت‌ها در نخاع آسیب‌دیده در بیماریزایی آسیب نخاعی ثانویه دخیل هستند. راهبردهای درمانی در مهار نفوذ لوکوسیت‌ها به محل آسیب‌دیده، بهبود آسیب‌های عصبی و ماده سفید نخاع پس از آسیب نخاعی را افزایش می‌دهد. اولین سلول‌هایی که به نخاع حمله می‌کنند، مونوسیت‌ها و نوتروفیل‌ها هستند. مونوسیت‌ها منشأ سایتوکاین‌ها، کموکاین‌های التهابی و استرس اکسیداتیو هستند که در طول 24 ساعت اولیه پس از آسیب نخاعی به محل آسیب‌دیده نفوذ کرده و در طی 4 تا 7 روز پس از آسیب به حداکثر مقدار خودشان می‌رسند. این مقاله به مرور نقش‌های متفاوت ماکروفاژها و مونوسیت‌ها و اثرات بالقوه آن‌ها در اتخاذ رویکردهای درمانی جدید در بیماران مبتلا به آسیب نخاعی می‌پردازد.
واژه‌های کلیدی: آسیب‌های طناب نخاعی، ماکروفاژها، مونوسیت‌ها
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نوع مطالعه: مروری | موضوع مقاله: تحقیقات پایه در علوم اعصاب
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Javdani M, Barzegar-Bafrouei A. The Key Role of Macrophages and Monocytes in Spinal Cord Injury: Development of Novel Therapeutic Approaches. Shefaye Khatam. 2020; 8 (4) :90-102
URL: http://shefayekhatam.ir/article-1-2158-fa.html

جاودانی موسی، برزگر بفروئی ابوالفضل. نقش کلیدی ماکروفاژها و مونوسیت‌ها در آسیب نخاعی؛ توسعه رویکردهای درمانی جدید. مجله علوم اعصاب شفای خاتم. 1399; 8 (4) :90-102

URL: http://shefayekhatam.ir/article-1-2158-fa.html



دوره 8، شماره 4 - ( پاییز 1399 ) برگشت به فهرست نسخه ها
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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