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:: Volume 10, Issue 3 (Summer 2022) ::
Shefaye Khatam 2022, 10(3): 37-47 Back to browse issues page
Neuroprotective Effect of Alpha-Pinene on Focal Cerebral Ischemia in Rats
Mahdieh Khoshnazar * , Bahram Farhadi Maghadam
Department of Animal Physiology, Ferdowsi University of Mashhad, Mashhad, Iran , m.khoshnazar@kmu.ac.ir
Abstract:   (1602 Views)
Introduction: Ischemic stroke is a severe neurological disorder that affected millions of people worldwide. Recent studies have shown that alpha-pinene has antioxidant effects during cerebral ischemia. The present study investigated the probable protective effects of alpha-pinene on brain infarction and neurological disability after a transient model of focal cerebral ischemia/reperfusion in rats. Materials and Methods: 30adult male Wistar rats whose weight ranged from 250 to 350 g were divided into five groups including a control group, a sham group, and three treatment groups. For ischemic stroke induction, the middle cerebral artery was occluded for 60 min followed by 24 hours of reperfusion. Alpha-pinene was injected intraperitoneally at the beginning of reperfusion. The neurologic outcome, infarct volume 2, 3, 5-Triphenyl tetrazolium chloride, and histological studies were done 24 hours after the end of artery occlusion. Results: The results showed that the application of alpha-pinene (50 and 100 mg/kg) led to a significant decrease in the infarct size as well as an improvement in neurobehavioral function. Moreover, alpha-pinene reduced the number of damaged neurons in the ischemic area. Conclusion: The findings of the current study indicated that olive oil effectively reduced ischemia, promoted reperfusion, and improved neurological outcomes. Olive oil is a potent neuroprotective factor that may prevent neurodegeneration of transient focal ischemia at the beginning of reperfusion at ischemic areas.
Keywords: Ischemic Stroke, Nervous System Diseases, Antioxidants, Brain Injuries
Full-Text [PDF 1323 kb]   (1463 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neurophysiology
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khoshnazar M, Farhadi Maghadam B. Neuroprotective Effect of Alpha-Pinene on Focal Cerebral Ischemia in Rats. Shefaye Khatam 2022; 10 (3) :37-47
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Volume 10, Issue 3 (Summer 2022) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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