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دوره 9 شماره 1 صفحات 166-188 برگشت به فهرست نسخه ها
مدل‌ها و آزمون‌‌های ارزیابی‌کنندۀ آسیب طناب نخاعی در موش صحرایی
غزال رحمنی، حمزه میرشکاری، فهیمه زواری، فریبا کریم زاده*
مرکز تحقیقات سلولی و مولکولی، دانشگاه علوم پزشکی ایران، تهران، ایران ، karimzade.f@iums.ac.ir
چکیده:   (244 مشاهده)
مقدمه: بهبود عملکرد، هدف اصلی مداخلۀ درمانی در مدل ‏های حیوانی بیماری‏ های مختلف است. برای آزمایش رویکردهای درمانی آسیب نخاعی (SCI)، تهیه یک مدل حیوانی SCI مناسب ضروری است. در این مدل، فرآیندهای پاتوفیزیولوژیک و تغییرات بافت‏ شناسی باید شبیه انسان باشد. به ‏نظر می‏رسد بسیاری از مکانیسم ‏های اثر دارو در SCI در نخاع انسان و حیوان مشابه هستند. در این مطالعه، ابتدا انواع اصلی مدل‏های تجربی SCI با کاربردهای مختلف بررسی شده است. در مرحله بعدی، آزمایشات رفتاری برای ارزیابی آسیب‏ های نخاعی ذکر شده است. نتیجه‌گیری: انتخاب یک مدل مناسب SCI  برای درستی انجام تحقیقات بسیار مهم است. اعتبار هر آزمون رفتاری به قابلیت اطمینان، اصالت و رایج بودن آن بستگی دارد. در این مقاله، علاوه بر نشان دادن مدل‌های مختلف و بررسی آزمایش ‏های ضایعۀ نخاعی، معیارهای انتخاب آن‏ ها و همچنین مزایا و معایب آن ‏ها مورد بحث قرار گرفته است.
واژه‌های کلیدی: آسیب‌های طناب نخاعی، مقیاس رتبه‌بندی رفتار، موش‌ های صحرایییی
متن کامل [PDF 2709 kb]   (49 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: تحقیقات پایه در علوم اعصاب
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Rahmani G, Mirshekari H, Zavvari F, karimzade ّ. A review on the models and evaluating tests of the spinal cord injury in rats. Shefaye Khatam. 2020; 9 (1) :166-188
URL: http://shefayekhatam.ir/article-1-2101-fa.html

رحمنی غزال، میرشکاری حمزه، زواری فهیمه، کریم زاده فریبا. مدل‌ها و آزمون‌‌های ارزیابی‌کنندۀ آسیب طناب نخاعی در موش صحرایی. مجله علوم اعصاب شفای خاتم. 1399; 9 (1) :166-188

URL: http://shefayekhatam.ir/article-1-2101-fa.html



دوره 9، شماره 1 - ( زمستان 1399 ) برگشت به فهرست نسخه ها
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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