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:: دوره 11، شماره 1 - ( زمستان 1401 ) ::
دوره 11 شماره 1 صفحات 153-133 برگشت به فهرست نسخه ها
نشانگرهای زیستی در ضربات مغزی
حوریه سادات ثابت ، فرشته سادات ثابت ، کریم شجاعی ، فائزه یعقوبی ، مریم جعفریان*
مرکز تحقیقات ضایعات مغز ونخاعی، پژوهشکده علوم اعصاب، دانشگاه علوم پزشکی تهران، تهران، ایران ، mjafarian@sina.tums.ac.ir
چکیده:   (829 مشاهده)
مقدمه: هدف این مطالعه مروری، به‌روز‌رسانی اهمیت بیومارکرهای موجود و همچنین نشانگرهای زیستی جدیدی است که در حال ظهور هستند و می‌توانند در آینده نزدیک به صورت بالینی امرد استفاده قرار بگیرند. در دو دهه اخیر با توجه به ناهمگانی در بروز و تشخیص ضربات مغزی، مطالعات مربوط به دستیابی به نشانگرهای زیستی برای غلبه بر این چالش بزرگ سلامت در جهان به طور تصاعدی افزایش یافته است. تشخیص بیومارکرهای مختلف، مانند مولکول‌های موجود در مایع مغزی نخاعی و خون، و همچنین روش‌های تصویربرداری، به طور گسترده مورد ارزیابی قرار گرفته‌اند. نتیجه‌گیری: در مطالعه متعددی، این نشانگرهای زیستی برای اندازه‌گیری شدت آسیب مغزی، شناسایی بیماران در معرض خطر بالاتر، پیامدهای نامطلوب پس از آسیب و پیش‌بینی مدت زمان بهبودی مورد استفاده قرار گرفتند. علیرغم پیشرفت قابل توجه در این زمینه، هر یک از نشانگرهای زیستی موجود محدودیت‌های خاص خود را دارند، بنابراین مطالعات زیادی بر روی نشانگرهای زیستی جدید مانند microRNA، وزیکول‌های خارج سلولی ونورومتابولیت‌ها در حال انجام است. در نتیجه، به‌روز‌رسانی یافته‌های جدید این بیومارکرها اهمیت بیولوژیکی و بالینی زیادی دارد.
واژه‌های کلیدی: نشانگرهای زیستی، مغز، زخم‌ها و جراحات
متن کامل [PDF 1599 kb]   (788 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: نوروبيولوژي مولكولي
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Sabet H S, Sabet F S, Shojaei K, Yaghoubi F, Jafarian M. Biomarkers in Traumatic Brain Injury. Shefaye Khatam 2022; 11 (1) :133-153
URL: http://shefayekhatam.ir/article-1-2362-fa.html

ثابت حوریه سادات، ثابت فرشته سادات، شجاعی کریم، یعقوبی فائزه، جعفریان مریم. نشانگرهای زیستی در ضربات مغزی. مجله علوم اعصاب شفای خاتم. 1401; 11 (1) :133-153

URL: http://shefayekhatam.ir/article-1-2362-fa.html



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